摘要
目的了解某焦化企业下风居民体内PAHs暴露水平及其影响因素。方法采用健康调查问卷收集常年居住于污染企业下风向的非职业人群健康信息,并采集尿样,利用高效液相色谱检测方法对尿样中多环芳烃羟基代谢产物2-羟基萘(2-OHNAP)、9-羟基芴(9-OHFLU)、1-羟基菲(1-OHPHE)、1-羟基芘(1-OHPYR)、3-羟基苯并[A]芘(3-OHB[a]P)作为生物标志物,进行检测;将5种代谢产物检出结果与人群性别、年龄分级、BMI指数以及每日吸烟量、平均喝酒频率、食用烧烤频率、户外活动时长等变量做Spearman秩相关分析;将5种代谢产物检出结果,对数转换作为因变量,上述变量为自变量,进行多重线性回归分析。结果Spearman秩相关分析结果表明2-OHNAP与每日吸烟量、吃烧烤频率呈正相关(P<0.01);1-OHPYR与年龄、每日吸烟量、户外活动时长呈正相关(P<0.01);1-OHPYR与年龄、每日吸烟量和户外活动时间呈正相关(P<0.01);3-OHB[a]P与户外活动时长呈正相关(P<0.01)。多重线性回归分析结果表明每日吸烟量越多,尿中2-OHNAP、9-OHFLU、1-OHPHE和3-OHB[a]P检出水平越高(P<0.05);每月食用烧烤频率越多,尿中1-OHPYR、3-OHB[a]P检出结果越高(P<0.05);户外活动时间越长,尿中1-OHPHE、1-OHPYR检出结果越高(P<0.05)。结论吸烟、食用烧烤频率以及户外活动时长均是该人群PAHs暴露的影响因素。
Objective To investigate the exposure level of polycyclic aromatic hydrocarbons(PAHs)in downwind residents of a coking plant and its influencing factors using the hydroxy metabolites(2-hydroxy naphthalene,9-hydoxy fluorene,1-hydroxy phenanthrene,1-hydroxy pyrene,and 3-hydroxy benzo[a]pyrene)of PAHs in the urine as biomarkers.Methods A health questionnaire was used to collect the health information of the non-occupational population who were long-term residents in the downwind areas of the polluting enterprise;meanwhile,their urine samples were collected for determination of hydroxy metabolites of PAHs using high-performance liquid chromatography.A Spearman correlation analysis was performed between the test results of the above 5 metabolites and variables such as population gender,age,body mass index,daily smoking quantity,mean drinking frequency,frequency of having barbecues,and duration of outdoor activities.A multiple linear regression analysis was performed taking the test results of the above five metabolites as dependent variables and the above seven variables as independent variables.Results The Spearman correlation analysis showed that 2-hydroxy naphthalene was positively correlated with daily smoking quantity and frequency of having barbecues(P<0.01);1-hydroxy phenanthrene and 1-hydroxy pyrene were positively correlated with age,daily smoking quantity,and duration of outdoor activities(P<0.01);3-hydroxy benzo[a]pyrene was positively correlated with duration of outdoor activities(P<0.01).The multiple linear regression analysis showed that an increased daily smoking quantity was associated with higher urine levels of 2-hydroxy naphthalene,9-hydoxy fluorene,1-hydroxy pyrene,and 3-hydroxy benzo[a]pyrene(P<0.05);an increased frequency of having barbecues per month was associated with higher urine levels of 1-hydroxy pyrene and 3-hydroxy benzo[a]pyrene(P<0.05);an increased duration of outdoor activities was associated with higher urine levels of 1-hydroxy phenanthrene and 1-hydroxy pyrene(P<0.05).Conclusion Smoking quantity,frequency of having barbecues,and duration of outdoor activities are influencing factors for exposure to PAHs in this population.
作者
张超
周小林
张婷
孟倩倩
薛振伟
刘占旗
李建军
张晶
ZHANG Chao;ZHOU Xiaolin;ZHANG Ting;MENG Qianqian;XUE Zhenwei;LIU Zhanqi;LI Jianjun;ZHANG Jing
出处
《环境卫生学杂志》
2020年第2期179-184,共6页
JOURNAL OF ENVIRONMENTAL HYGIENE
关键词
多环芳烃
吸烟
食用烧烤频率
户外活动时长
polycyclic aromatic hydrocarbons
smoking
frequency of having barbecues
duration of outdoor activities
作者简介
张超,研究实习员,从事环境医学研究,联系方式:山西省太原市小店区学府街102号,邮编:030000,Email:546959268@qq.com;通信作者:周小林,研究员,从事环境医学研究,Email:xiaolin8824@sohu.com。
