摘要
肿瘤干细胞(CSC)是一类具有肿瘤起始、自我更新及无限增殖潜能的细胞亚群,与肿瘤的局部复发与远处转移密切相关,是肿瘤放射治疗抵抗的根源。非小细胞肺癌是目前发病率及致死率较高的恶性肿瘤,已证实非小细胞肺癌中具有干细胞特性的CSC亚群,目前通过分离CD133等一系列已知免疫表型阳性细胞是获得非小细胞肺癌CSC的主要手段。研究证实CSC主要是通过DNA损伤、细胞自噬和缺氧肿瘤微环境等机制介导非小细胞肺癌的放疗抵抗效应。本文主要对非小细胞肺癌CSC的生物学特性、免疫表型表达及放疗抵抗的分子机制进行综述,以期为提高非小细胞肺癌放射疗效提供线索和依据。
Cancer stem cell(CSC)is a kind of cell subpopulation with the tumor initiation potential,self-renewal and unlimited proliferation.It is closely related to local recurrence and distant metastasis of tumors as well as the root cause of resistance to radiotherapy.Non-small-cell lung cancer is a malignant tumor with high incidence and mortality rate.It has been confirmed that CSC subsets with stem cell characteristics in non-small-cell lung cancer.At present,CSCs of non-small-cell lung cancer are mainly obtained by isolating a series of cells with immunophenotypes such as CD133.CSC mediates the radiotherapy resistance of non-small-cell lung cancer through mechanisms such as DNA damage,cell autophagy,and hypoxic tumor microenvironment.In this review,the biological characteristics,immunophenotypic expression and the molecular mechanism of radiotherapy resistance of CSC in non-small-cell lung cancer were reviewed in order to provide relevant evidence for the improvement of radiotherapy efficacy in non-small-cell lung cancer.
作者
何环宇
姜笑
张琨明
杨育坤
王茂
李懿
He Huanyu;Jiang Xiao;Zhang Kunming;Yang Yukun;Wang Mao;Li Yi(Kunming Medical University Graduate School,Kunming 650031,China;Department of Oncology,920th Hospital of Joint Logistics Support Force,Kunming 650032,China)
出处
《中华细胞与干细胞杂志（电子版）》
2020年第3期177-181,共5页
Chinese Journal of Cell and Stem Cell（Electronic Edition）
基金
国家自然科学基金(81960551)
云南省自然科学基金重点项目(2016FA038)。
关键词
肿瘤干细胞
非小细胞肺癌
放疗
Cancer stem cells
Non-small-cell lung cancer
Radiotherapy
作者简介
通信作者:李懿,Email:liyi3443@hotmail.com。
