摘要
目的:探究盐酸纳美芬注射液在治疗窒息新生儿中的应用,及其对患儿转归、血浆肌酸激酶同工酶MB(CK-MB)、N末端B型利钠肽原(NT-proBNP)、β-内啡肽(β-EP)表达的影响。方法:选取2016年12月~2018年12月我院收治的58例窒息新生儿列为研究对象,按随机数字表法以1∶1的比例分为对照组和研究组(n=29)。对照组患儿使用常规对症治疗,研究组则在常规治疗上接受盐酸纳美芬注射液治疗,治疗时间为3天,对比两组治疗后患儿的机械辅助通气时间及住院时间、患儿并发症发生情况,治疗前后新生儿行为神经评分(NBNA)、血浆CK-MB、NT-proBNP、β-EP水平,随访半年,观察并记录患儿的后遗症发生情况。结果:研究组患儿机械辅助通气时间及住院时间均短于对照组(P<0.05);研究组患儿并发症发生率为6.90%,低于对照组的27.59%(P<0.05);两组患儿NBNA评分较治疗前上升,且研究组NBNA评分高于对照组(P<0.05);两组患儿的CK-MB、NT-proBNP、β-EP均较治疗前下降(P<0.05),且研究组患儿上述指标与对照组对比有统计学差异(P<0.05);随访半年期间,两组患儿均未出现死亡,研究组患儿的后遗症发生率为6.90%,对照组为20.69%,但两组无统计学差异(P>0.05)。结论:盐酸纳美芬注射液治疗窒息新生儿疗效显著,可缩短机械通气时间及住院时间,并发症较少,减轻患儿心、脑部损伤,也可减少患儿后遗症,安全性较好。
Objective:To explore the application of nalmefene hydrochloride in neonates with asphyxia,and its effects on outcomes and expressions of plasma creatine kinase isoenzyme MB(CK-MB),N-terminal B-type natriuretic peptide(NT-proBNP)andβ-endorphin(β-EP).Methods:A total of 58 neonates with asphyxia admitted to our hospital from December 2016 to December 2018 were included in the study and divided into control group and study group according to the random number table method,with 29 cases in each group.Control group was given routine symptomatic therapy,while study group was treated with additional nalmefene hydrochloride on that basis.The treatment course lasted for 3 days.Mechanically assisted ventilation time,hospital stay,complications after treatment,Neonatal Behavioral Neurological Assessment(NBNA),levels of plasma CK-MB,NT-proBNP andβ-EP before and after treatment were compared between the two groups.The occurrence of sequelae in patients was observed during a 6-month follow up.Results:The mechanically assisted ventilation time and the hospital stay in the study group were significantly shorter than those in control group(P<0.05).The incidence rate of complications in study group was significantly lower than that in control group(6.90%vs 27.59%,P<0.05).After treatment,the NBNA scores of the two groups increased compared to before treatment,and the improvement of NBNA score in study group was significantly better than that in control group(P<0.05).After treatment,the levels of CK-MB,NT-proBNP andβ-EP in both groups were significantly decreased compared with those before treatment(P<0.05),and the differences between study group and control group were significant after treatment(P<0.05).During half a year of follow-up,no death occurred in both groups.The incidence rate of sequelae was 6.90%in study group and 20.69%in control group(P>0.05).Conclusion:Nalmefene hydrochloride has significant efficacy for the treatment of neonates with asphyxia,which can reduce mechanical ventilation,hospital stay,complications,heart and brain damage,and suppress the sequelae of children patients,with high safety and good application value.
作者
何青
HE Qing(Department of Pediatrics,Puyang Oilfield General Hospital,Puyang 457001,China)
出处
《中国合理用药探索》
CAS
2020年第6期65-69,共5页
Chinese Journal of Rational Drug Use
作者简介
何青,女,副主任医师,研究方向:新生儿疾病。E-mail:tangnao7361929@163.com。
