摘要
目的设计一种可用于NO吸入治疗的便携式NO救治仪。方法NO救治仪采用模块化设计,可方便地调节各关键参数。其使用低强度、高频率的脉冲放电方式对大气压下干燥的空气进行脉冲放电,产生NO混合气体;采用Ca(OH)2颗粒来过滤放电过程中产生的NO2气体。基于该NO救治仪系统,研究气流方向、气体流量和输入电压对NO混合气体中的NO和NO2水平的影响;研究NO2去除装置对NO2的过滤性能。结果当空气从反应舱的阴极流入,阳极流出,且气体流量为2 L/min、输入电压为4 V时,系统性能较好。此时,输出气体中NO的体积分数为3.25×10^-5,NO2/NO为0.05。结论本研究提出的NO救治仪可满足医用NO气体需求,且系统性能稳定、体积便携、成本较低,在肺动脉高压、慢性阻塞性肺等疾病的治疗中有广泛的应用前景。
Objective To design a portable NO rescue device that can be used for NO inhalation therapy.Methods The NO rescue device adopts a modular design,and the key parameters can be easily adjusted.The device uses a low-intensity,high-frequency pulse discharge method to produce NO mixed gas by ionizing dry air at atmospheric pressure,and uses Ca(OH)2 particles to filter the NO2 gas in the NO mixed air.Based on the NO rescue device,the effects of airflow direction,gas flow rate and input voltage on the levels of NO and NO2 in the NO mixed gas were studied.The NO2 filtering performance of the NO2 removal device in the device was also studied.Results When the air flows in from the cathode and flows out from the anode of the reaction chamber,and the flow rate and input voltage respectively were 2 L/min and 4 V,the system had a better performance.At this condition,the volume fraction of NO in the output gas is 3.25×10^-5,and NO2/NO is about 0.05.Conclusions The proposed NO rescue device can meet the needs of medical NO gas,and the system has stable performance,portable volume,and low cost,and has broad application prospects in the treatment of pulmonary hypertension and chronic obstructive pulmonary diseases.
作者
李倩
王宏
张文露
王琳琳
沙洪
Li Qian;Wang Hong;Zhang Wenlu;Wang Linlin;Sha Hong(Institute of Biomedical Engineering,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin 300192,China)
出处
《国际生物医学工程杂志》
CAS
2020年第1期50-54,64,共6页
International Journal of Biomedical Engineering
关键词
一氧化氮
吸入疗法
便携式
脉冲放电
Nitric oxide
Inhalation therapy
Portable
Pulsed discharge
作者简介
通信作者:沙洪,Email:shahong2000@163.com。
