摘要
脓毒症是由于宿主对感染反应失调引起的一种危及生命的全身炎症反应综合征(SIRS),最终导致脓毒性休克和多器官功能衰竭。研究表明胰腺损伤是脓毒症中重要的病理学改变。自噬是维持细胞物质和能量正常代谢的重要途径,在许多疾病中均发挥重要作用。新近研究发现,自噬对脓毒症胰腺损伤发挥双重作用,适度自噬可以减轻胰腺损伤;过度自噬可造成与凋亡相关的自噬性细胞死亡从而加重胰腺损伤。脓毒症中活化的核转录因子-κB(NF-κB)对自噬有促进作用,溶酶体相关膜蛋白(LAMP)降解可造成自噬流受损而加重胰腺损伤。对脓毒症胰腺损伤中自噬变化机制的探索将有助于恢复正常自噬功能,从而为治疗脓毒症胰腺损伤寻找新的靶点。
Sepsis is a life-threatening systemic inflammatory response syndrome(SIRS)caused by the host's maladjustment response to infection,which eventually leads to septic shock and multiple organ failure.Pancreatic injury was found to be an important pathological change in sepsis.Autophagy is a crucial way to maintain the normal metabolism of cell substances and energy,which plays an important role in many diseases.Recent studies have found that autophagy plays a dual role in pancreatic injury in sepsis.Moderate autophagy can protect the pancreas and reduce the injury,while excessive autophagy can cause apoptosis-related autophagic cell death and aggravate the pancreatic injury.In sepsis,activated nuclear factor-κB(NF-κB)has a promoting effect on autophagy,and lysosome associated membrane protein(LAMP)degradation can result in impaired autophagy flux and aggravate pancreatic injury.The exploration of the mechanism of autophagy in pancreatic injury of sepsis will help to restore the normal autophagy function,so as to find a new target for the treatment of pancreatic injury of sepsis.
作者
李悦娴
索良源
张锦
Li Yuexian;Suo Liangyuan;Zhang Jin(Department of Anesthesiology,Shengjing Hospital of China Medical University,Shenyang 110004,Liaoning,China;Department of Anesthesiology,Cancer Hospital of China Medical University,Shenyang 110042,Liaoning,China)
出处
《中华危重病急救医学》
CAS
CSCD
北大核心
2020年第4期504-507,共4页
Chinese Critical Care Medicine
基金
辽宁省沈阳市科技计划项目(17-230-9-45)。
作者简介
通信作者:张锦,Email:zhangj_sj@163.com。
