摘要
目的调查秦皇岛地区老年戊型肝炎(hepatitis E,HE)的流行病学和临床特点。方法收集秦皇岛市第一医院诊治的老年HE患者(≥60岁)的临床资料,分析其流行病学和临床特点。结果2015-2018年间来我院就诊的老年HE患者132例,其中男性102例,占73.27%。32例合并基础肝病,45例合并糖尿病、冠心病等其他慢性疾病。第4季度发病人数最多,占37.12%。与单纯老年HE患者比较,合并基础肝病的患者TBIL、ALT、AST水平显著增高,胆碱酯酶(cholinesterase,CHE)水平和PTA下降(P均<0.05)。与单纯老年HE患者比较,合并其他慢性疾病患者TBIL水平显著增高,PTA降低(P均<0.05)。单纯老年HE患者病死率为3.64%(2/55),合并基础肝病患者的病死率为21.88%(7/32),合并其他慢性疾病患者病死率为13.33%(6/45),3类患者病死率比较,差异有统计学意义(P<0.05)。结论老年HE男性发病率显著高于女性,主要发生在第4季度,合并慢性疾病尤其基础肝病的老年患者病情较重,病死率较高。
Objective To investigate the epidemiological and clinical features of senile patients with hepatitis E(HE)in Qinhuangdao.Methods Clinical data of senile patients(≥60 years old)with HE admitted to the First Hospital of Qinhuangdao were collected.Epidemiological characteristics and clinical profiles were analyzed.Results From 2015 to 2018,132 senile patients with HE were treated in our hospital,and 102(73.27%)of them were males.Thirty-two cases were complicated with underlying basic liver diseases,and 45 cases were complicated with other chronic diseases such as diabetes and coronary heart disease.The number of affected cases was dominant in the fourth quarter,accounting for 37.12%.Compared with senile patients with sporadic HE,those senile patients with liver diseases showed significantly higher TBIL,ALT,AST levels,lower cholinesterase(CHE)and PTA levels(P<0.05).Compared with senile patients with sporadic HE,those senile patients with other chronic underlying diseases showed significantly a higher TBIL level,lower PTA level(P<0.05).The case fatality rate of senile patients with sporadic HE was 3.64%(2/55),that of senile HE patients with liver diseases was 21.88%(7/32)and that of senile HE patients with other diseases was 13.33%(6/45),with statistically significant differences(P<0.05).Conclusions The incidence of HE in male senile patients is significantly higher than that in female senile patients.HE in senile patients mainly occurrs in the fourth quarter.The medical condition of senile HE patients with chronic especially underlying liver diseases is relatively severe,with a high case fatality rate.
作者
卜秋宁
王术艺
马翠花
郝殿晋
张钰
石华
BU Qiu-ning;WANG Shu-yi;MA Cui-hua;HAO Dian-jin;ZHANG Yu;SHI Hua(Department of Clinical Laboratory,First Hospital of Qinhuangdao,066600,China)
出处
《传染病信息》
2020年第3期239-242,共4页
Infectious Disease Information
基金
河北省秦皇岛市科技研究与发展指导计划项目(201805A072)。
关键词
戊型肝炎
老年
流行病学
临床特点
hepatitis E(HE)
senile
epidemiology
clinical feature
作者简介
通信作者:卜秋宁,E-mail:buqiuning@163.com。
