摘要
目的:分析医院2018年药品不良反应(ADR)发生特点及规律,为临床合理用药提供参考。方法:抽取2018年1月1日—12月31日期间上报广东省药品不良反应管理平台的ADRs报告512例、分析其不良反应发生的相关因素。结果:512例ADRs报表中,涉及患者男性238例(占46.48%)和女性274例(占53.52%);发生ADRs患者年龄段最高在61~70岁之间111例(占21.68%);给药途径中涉及622例,其中静脉滴注给药导致ADRs 452例(占72.67%);ADRs涉及药品的用药患者622例,其中抗微生物药物引发ADRs患者204例(占32.80%);ADRs累及器官/系统1001例,主要为皮肤及附件和器官292例占29.17%,皮疹、瘙痒是最典型的症状。结论:ADRs发生与患者年龄、给药途径、药品种类等因素存在相关性,临床对ADRs监测应重点关注上述影响因素,并结合患者症状实施个体化给药,提高临床合理用药水平,以确保患者用药的安全性。
Objective:To analyze the characteristics and rules of adverse drug reactions(ADR)in 2018,and to provide references for rational use of drugs in clinic.Methods:512 cases of ADRs reported to the Guangdong ADR Monitoring System collected from January 1 to December 31,2018 were selected to analyze the factors related to the occurrence of ADRs.Results:In the 512 cases of ADRs,the male patient 238(46.48%)and female patients 274(53.52%)were involved.The highest age of patients with ADRs was between 61 and 70 years old(111 cases,21.68%).The route of administration involved 622 cases,in which 452 cases(72.67%)were caused by intravenous drip administration.Among the 622 patients with ADRs involving drugs,204 patients with ADRs induced by antimicrobial drugs accounted for 32.80%.There were 1001 cases of ADRs involving organs/system,mainly 292 cases of skin,appendages and organs,accounting for 29.17%.the rash and pruritus were the most typical symptoms.Conclusion:The occurrence of ADRs is correlated with the patient’s age,drug route,drug type and other factors.Clinical monitoring of ADRs should focus on the above influencing factors,and carry out individualized drug administration in combination with the patient’s symptoms,so as to improve the level of clinical rational drug use and to ensure the safety of drug use.
作者
邱小婷
陈耀哲
宋兴栋
QIU Xiao-ting;CHEN Yao-zhe;SONG Xing-dong(Department of Pharmacy,Huizhou Municipal Central Hospital,Huizhou Guangdong 516000,China)
出处
《抗感染药学》
2020年第5期720-724,共5页
Anti-infection Pharmacy
关键词
药品不良反应
特点及规律
合理用药
相关因素
adverse drug reactions
characteristics and rules
rational clinical use of drugs
factors related
作者简介
邱小婷(1985-),女,主管药师.联系电话:0752-2288052,E-mail:tougaomail00@163.com。
