摘要
胰腺癌是恶性程度最高的消化道肿瘤,早期诊断困难,手术切除率低,对放化疗不敏感,预后极差。外泌体是稳定存在于体液中的一类包含有蛋白质、RNA、DNA和脂质等生物活性分子的双层脂质小体。作为肿瘤微环境的重要组成部分,外泌体与胰腺癌的恶性表型及耐药等生物学行为有相关性;作为潜在的分子标志物,外泌体检测对于胰腺癌的早期诊断、疗效评估及肿瘤复发监测等有潜在应用价值。
Pancreatic ductal adenocarcinoma(PDAC)is one of the worst digestive malignancies.The prognosis of this disease remains dismal since the facts that it is difficult to be diagnosed in early stage,has a low rate of surgical resection,and is not sensitive to conventional chemoradiotherapy.Exosomes are a kind of bilayer lipid bodies containing a variety of bioactive molecules,such as proteins,RNA,DNA,lipid,and exist stably in body fluids.As an important component in tumor microenvironment,exosomes are correlated with the malignant phenotype and chemoreistance of pancreatic cancer;as a potential diagnostic biomarker,exosome detection has potential application value in early diagnosis,efficacy evaluation,and tumor recurrence monitoring of pancreatic cancer.
作者
李明浙
杨尹默
Li Mingzhe;Yang Yinmo(Department of General Surgery,Peking University First Hospital,Beijing 100034,China)
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2020年第1期1-4,共4页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金(81871954)。
关键词
胰腺癌
外泌体
肿瘤微环境
生物标志物
Pancreatic ductal adenocarcinoma
Exosome
Tumor microenvironment
Biomarker
作者简介
通信作者:杨尹默,Email:yangyinmo@263.net。
