摘要
目的比较头孢替安和头孢哌酮/舒巴坦治疗肾功能不全伴呼吸系统感染患者的成本和疗效,为该类特殊人群临床合理用药提供参考。方法回顾性统计分析安徽省3家三级甲等医院2017年1月-2017年12月肾功能不全住院患者中使用抗菌药物的情况,在综合考虑抗感染治疗效果和药品不良反应的基础上,运用最小成本分析法对用药频次前2名的头孢类药物(头孢替安vs头孢哌酮/舒巴坦)进行药物经济学评价。结果纳入头孢替安和头孢哌酮/舒巴坦治疗的有效病例各85例。2组抗菌治疗的临床痊愈率(92.94%vs 95.29%,P=0.746)无显著性差异。住院期间均未发现明显药品不良反应,故采用最小成本分析法对2组进行成本效果分析,结果显示头孢替安组的平均直接医疗成本低于头孢哌酮/舒巴坦组($437.46 vs$682.28,P<0.001)。结论与头孢哌酮/舒巴坦相比,头孢替安用于治疗肾功能不全伴呼吸系统感染患者更具有经济性。
OBJECTIVE To evaluate the cost-effectiveness of cefotiam and cefoperazone/sulbactam in treating respiratory system infections with renal insufficiency patients and to provide reference for clinical rational use of drugs in this special group. METHODS In regard to the use of antibiotics in hospitalized patients with renal insufficiency from January 2017 to December 2017, a retrospective, multi-center cohort study was conducted in three large-scale general hospitals in Anhui province. Based on treatment effects and adverse drug reactions, cost-minimization analysis was used to evaluate the top two cephalosporins(cefotiam vs cefoperazone/sulbactam) for pharmacoeconomic evaluation. RESULTS Eighty-five patients treated with cefotiam and eighty-five with cefoperazone/sulbactam were included. There was no significant difference in the clinical effective rate between the two groups(92.94% vs 95.29%, P=0.746). No significant adverse reactions were found during hospitalization. A cost-minimization analysis was adopted for economic evaluation. Medical costs was lower in cefotiam group for respiratory system infections with renal insufficiency patients($437.46 vs $682.28, P<0.001). CONCLUSION Cefotiam is more economical than cefoperazone/sulbactam in treating respiratory system infections with renal insufficiency patients.
作者
陈晓雨
周昕
张子豪
柳杨
杨雅茹
沈爱宗
解雪峰
CHEN Xiaoyu;ZHOU Xin;ZHANG Zihao;LIU Yang;YANG Yaru;SHEN Aizong;XIE Xuefeng(Anhui Medical University,Hefei 230032,China;The Second Affiliated Hospital of Anhui Medical University,Hefei 230601,China;The First Affiliated Hospital of University of Science and Technology of China,Hefei 230001,China)
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2020年第6期714-718,共5页
Chinese Journal of Modern Applied Pharmacy
基金
2018年安徽省高校优秀青年人才支持计划项目(gxyq2018006)
2019年国家大学生创新创业训练计划项目(201910366042)。
关键词
头孢替安
头孢哌酮
肾功能不全
呼吸系统感染
药物经济学评价
cefotiam
cefoperazone
renal insufficiency
respiratory system infections
pharmacoeconomic evaluation
作者简介
陈晓雨,女,硕士生,Tel:15805609760,E-mail:ahmuphcxy@outlook.com;通信作者:解雪峰,女,博士,副教授,硕导,Tel:13721098599,E-mail:xiexuefeng@ahmu.edu.cn。
