摘要
目的:探讨高压氧辅助治疗新型冠状病毒肺炎(COVID-19)的临床疗效及其不同介入时机对疗效的影响。方法:回顾性分析湖北医药学院附属东风医院2020年1~3月收治的符合《新型冠状病毒感染的肺炎诊疗方案(试行第五版)》诊断标准的患者88例,按是否进行高压氧治疗分为常规治疗组(50例)及高压氧辅助治疗组(38例),比较两组患者治疗后在核酸转阴时间、CT病灶吸收好转时间、淋巴细胞恢复正常时间及住院时间等方面的差异。同时将高压氧辅助治疗的COVID-19(普通型)患者33例按介入时机分为早期组(入院1~10 d)15例、晚期组(入院后10 d)18例,比较两组患者间在住院时间上的差异。结果:高压氧辅助治疗组的核酸转阴时间、CT病灶吸收好转时间、淋巴细胞恢复正常时间、住院时间均短于常规治疗组,介入高压氧治疗早期组住院时间明显优于晚期组,差异均有统计学意义(P<0.05)。结论:在常规治疗的基础上辅以高压氧治疗可以加快COVID-19患者核酸转阴、CT病灶吸收及淋巴细胞恢复时间,缩短住院时间,并且高压氧介入时间越早住院时间越短。
Objective To investigate the therapeutic efficacy of adjuvant hyperbaric oxygen therapy(HBO)against COVID-19 and the effects of timing of intervention on the efficacy.Methods The clinical information of 88 patients who met the criteria for COVID-19 protocol(the fifth trial edition)and were treated in Affiliated Dongfeng Hospital,Hubei University of Medicine from January to March in 2020 were studied retrospectively.A according to treatment methods,the patients were divided into conventional treatment group(n=50)and adjuvant HBO group(n=38).The differences in the indexes including the time of negative transformation of nucleic acid,the time of CT improvement,the time of lymphocyte normalization and hospital stay between two groups were compared.Meanwhile,33 patients with ordinary type of COVID-19 in adjuvant HBO group were further divided into early phase group(1-10 days after admission to hospital,n=15)and late phase group(>10 days after admission to hospital,n=18 patients)to compare the differences in hospital stays.Results Compared with those in conventional treatment group,the patients in adjuvant HBO group achieved the negative transformation of nucleic acid,CT improvement and lymphocyte normalization earlier,and had a shorter hospital stay in adjuvant HBO group was shorter than that in conventional treatment group.Moreover,the hospital stay in early phase group was shorter than that in late phase group,with statistical differences(P<0.05).Conclusion Adjuvant HBO plus conventional treatment can accelerate the time of negative transformation of nucleic acid,CT improvement,lymphocyte normalization,and shorten hospital stays,and the earlier HBO is adopted,the shorter the hospital stay is.
作者
杨勇
吴慕禹
苗丽霞
贺聪
YANG Yong;WU Muyu;MIAO Lixia;HE Cong(Department of Geriatric Medicine,Affiliated Dongfeng Hospital,Hubei University of Medicine,Shiyan 442008,China;Department of Critical Care Medicine,Affiliated Dongfeng Hospital,Hubei University of Medicine,Shiyan 442008,China;Department of Hyperbaric Oxygen,Affiliated Dongfeng Hospital,Hubei University of Medicine,Shiyan 442008,China)
出处
《中国医学物理学杂志》
CSCD
2020年第5期641-643,共3页
Chinese Journal of Medical Physics
基金
十堰市科技局新冠肺炎防控技术引导性应急科研项目(20Y57)。
作者简介
杨勇,硕士,副主任医师,主要从事老年重症临床工作,E-mail:26738720@qq.com;通信作者:贺聪,副主任医师,主要从事高压氧治疗工作,E-mail:dfzyyhc@126.com。
