摘要
目的多指标综合评价结合中心组合设计(BBD)响应曲面法优选煨木香的炮制工艺。方法以煨木香的外观性状、挥发油、木香烃内酯、去氢木香内酯含量的综合评分为评价指标,采用BBD响应曲面法对平铺层数、纸煨温度、纸煨时间进行考察,筛选最佳炮制工艺参数,并对优化后的炮制工艺进行验证。结果煨木香的最佳炮制工艺为:将湿木香饮片用1层草纸包裹后,间隔平铺5层,置100℃烘箱中烘煨约2 h,木香呈棕黄色取出。结论优选出的木香纸煨炮制工艺简单、可行、稳定,能为制定木香饮片的炮制工艺和标准规范提供依据。
Objective To optimize the processing technology of roasted Aucklandiae Radix by multi index comprehensive score combined with box-behnken design(BBD)response surface methodology.Methods The appearance character,volatile oil,costunolide and dehydrocostuslactone of the roasted Aucklandiae Radix were taking as the comprehensive evaluation indexes.The BBD response surface method was used to investigate the number of tile layers,paper simmering temperature and paper simmering time,select the best processing parameters,and verify the optimized processing process.Results The optimal processing technology of roasted Aucklandiae Radix was as follows:the wet Aucklandiae Radix was wrapped with a layer of straw paper,laying them in five layers at intervals,place them in a 100℃oven and bake them for about 2 hours,and taking them out when they present brown.Conclusion The optimized processing technology of the paper-roasted Aucklandiae Radix is simple,feasible and stable,which can provide a basis for the setting of processing technology and standard specifications of the paper-roasted Aucklandiae Radix.
作者
陈娟
李跃辉
王银
彭宇
彭俊
彭艳梅
肖德华
CHEN Juan;LI Yuehui;WANG Yin;PENG Yu;PENG Jun;PENG Yanmei;XIAO Dehua(Hu′nan Institute of Traditional Chinese Medicine,Hu′nan Province,Changsha410006,China;Hu′nan ProvinceEngineeringResearch Center for Quality Evaluation and Traceability of Traditional Chinese Medicine Preparations,Hu′nan Province,Changsha410006,China)
出处
《中国医药导报》
CAS
2020年第15期12-16,共5页
China Medical Herald
基金
湖南省科技厅重点研发项目(2017SK2121)
湖南省科技创新计划项目(2018TP2035)。
关键词
煨木香
多指标评价
中心组合设计响应曲面法
木香烃内酯
去氢木香内酯
Roasted Aucklandiae Radix
Multi-index evaluation
Box-behnken design response surface
Costunolide
Dehydrocostuslactone
作者简介
陈娟(1980-),女,硕士,主要从事中医药科研和管理工作;通讯作者:肖德华(1967-),男,主任药师,主要从事中药研究工作;通讯作者:李跃辉(1978-),女,硕士,研究员,主要从事中药制剂研究工作。
