摘要
目的探讨抗结核药物所致药物性肝损害的临床特点。方法选择我院2018年1月~2019年7月收治的60例抗结核药物使用患者作为本次研究入组对象,回顾性分析患者抗结核药物后出现药物性肝损害的情况。结果不同性别结核患者抗结核药物所致药物性肝损害情况男性结核患者肝损害发生率为8.82%(3/34),女性结核患者肝损害发生率为11.54%(3/26)。男女性别间抗结核药物所致药物性肝损害发病率无明显差异(P>0.05)。不同年龄段结核患者抗结核药物所致药物性肝损害情况中,60岁以下结核患者肝损害发生率为5.56%(2/36),60岁或以上结核患者肝损害发生率为16.67%(4/24)。不同年龄段间抗结核药物所致药物性肝损害发病率差异有统计学意义(P<0.05)。60岁以下年龄患者ALT、AST、T-BIL、γ-GT、ALB等指标优于60岁或以上年龄患者,差异有统计学意义(P<0.05)。结论抗结核药物所致药物性肝损害发病率较高,老年人高发,密切定期检测早期诊断和治疗药物性肝损害,防止肝功能进一步恶化。
Objective To explore the clinical characteristics of drug-induced liver damage caused by anti-tuberculosis drugs.Methods 60 patients with anti-tuberculosis drugs admitted to our hospital from January 2018 to July 2019 were selected as the study subjects.The drug-induced liver damage after anti-tuberculosis drugs was retrospectively analyzed.Results The distribution of drug-induced liver damage caused by anti-tuberculosis drugs in different sex:the incidence in male was 8.82%(3/34)and 11.54%(3/26)in female,and there was no significant difference in the incidence between male and female(P>0.05).The distribution of drug-induced liver damage caused by anti-tuberculosis drugs in different age group:the incidence of liver damage in tuberculosis patients under 60 years was 5.56%(2/36),and 16.67%(4/24)in 60 years or older patients,and there was a statistically significant difference in the incidence between different age groups(P<0.05).The alanine aminotransferase(ALT),aspartate aminotransferase(AST)total bilirubin(T-BIL),γ-glutamyl transpeptidase(γ-GT),albumin(ALB)and other indicators of patients under 60 years were better than those of patients over 60 years,and the differences were statistically significant(P<0.05).Conclusion The incidence of drug-induced liver damage caused by anti-tuberculosis drugs is high,particularly in elderly patients.It is necessary to carry out early diagnosis and treatment of drug-induced liver damage to prevent further deterioration of liver function.
作者
刘国华
LIU Guohua(Department of Respiratory Medicine,Jiangxi Chest Hospital,Nanchang330100,China)
出处
《中国现代医生》
2020年第10期107-109,共3页
China Modern Doctor
关键词
抗结核药物
药物性
肝损害
肝功能检查
预防
Anti-tuberculosis drugs
Drug properties
Liver damage
Liver function tests
Prevention
