摘要
目的:分析阿托伐他汀强化治疗对冠心病经皮冠状动脉介入(PCI)术后血小板活化及血管内皮功能的影响。方法:选取我院106例冠心病患者随机数字表法分为观察组(n=53)与对照组(n=53),均行PCI术,术后给予对照组常规剂量阿托伐他汀治疗,给予观察组阿托伐他汀强化治疗,比较两组治疗前后血小板活化指标。结果:疗程结束后,观察组血清NO水平较对照组高,ET-1较对照组低(P<0.05),观察组GPⅡb/Ⅲa、CD62p较对照组低(P<0.05)。结论:阿托伐他汀强化治疗可显著抑制冠心病PCI术后患者血小板活化,提高血管内皮功能。
Objective:To analyze the effects of intensive treatment with atorvastatin on platelet activation and vascular endothelial function in patients with coronary heart disease after percutaneous coronary intervention(PCI).Methods:106 patients with coronary heart disease enrolled in our hospital were randomized into the observation group(n=53)and control group(n=53).All patients underwent PCI.Patients in the control group were given conventional atorvastatin treatment,while patients in the observation group were given intensive treatment with atorvastatin after PCI.The platelet activation index of both groups were compared before and after treatment.Results:After the treatment,the serum NO level in the observation group was higher than that in the control group,and the ET-1 was lower than that in the control group(P<0.05).The GPIIb/IIIa and CD62p in the observation group were lower than those in the control group(P<0.05).Conclusion:Intensive treatment with atorvastatin can significantly inhibit platelet activation and improve endothelial function in patients with coronary heart disease after PCI.
作者
冯胜义
焦保义
FENG Shengyi;JIAO Baoyi(Dept.of Internal Medicine,Staff Hospital of Luoyang Julong Communication Equipment Group Co.,Ltd.,Luoyang 471000;The 1st Dept.of Internal Medicine,the 6th People’s Hospital of Luoyang,Luoyang 471000,China)
出处
《华夏医学》
CAS
2019年第5期58-61,共4页
Acta Medicinae Sinica
关键词
阿托伐他汀
冠心病经皮冠状动脉介入术
血小板活化
血管内皮功能
atorvastatin
percutaneous coronary intervention for coronary heart disease
platelet activation
endothelial function
