摘要
【目的】观察运用阳中隐阴法针刺治风六穴治疗慢性荨麻疹的临床疗效,并探讨其可能的作用机制。【方法】将90例慢性荨麻疹患者随机分为治疗组和对照组,每组各45例。治疗组运用阳中隐阴法针刺治风六穴治疗;对照组给予口服氯雷他定片治疗,每次10 mg,每日1次。连续治疗6周。治疗6周后,比较2组患者治疗前后症状积分、血清白细胞介素-4(IL-4)、免疫球蛋白E(IgE)和γ-干扰素(IFN-γ)的变化情况,并评价其安全性。【结果】(1)研究过程中,治疗组失访1例,对照组失访1例。最终治疗组44例、对照组44例纳入疗效统计。(2)治疗后,2组患者的症状积分均明显改善(P<0.05),且治疗组在改善症状积分方面明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患者的IL-4、IgE、IFN-γ水平均明显改善(P<0.05),且治疗组在改善IL-4、IgE、IFN-γ水平方面均明显优于对照组,差异均有统计学意义(P<0.05)。(4)治疗组总有效率为93.18%(41/44),对照组为75.00%(33/44)。治疗组疗效优于对照组,差异有统计学意义(P<0.05)。(5)安全性评价:2组患者的血压、心率在整个研究期间维持稳定。对照组中有1例患者出现恶心、纳差的症状,治疗组中有1例患者出现头晕的症状,但均不影响临床治疗,停止治疗后均恢复。治疗结束1个月后随访,治疗组复发率为4.55%,对照组复发率为22.73%,治疗组复发率明显优于对照组,差异有统计学意义(P<0.05)。【结论】运用阳中隐阴法针刺治风六穴治疗慢性荨麻疹能明显改善慢性荨麻疹患者瘙痒和风团的临床症状,对患者血清IL-4、IgE和IFN-γ水平有明显的调节作用。
Objective To observe the clinical effect of acupuncture for treatment of chronic urticaria at six Feng points by first reinforcement and second reduction and explore its possible mechanism. Methods Ninety patients with chronic urticaria were randomly divided into treatment group and control group,45 cases in each group. The treatment group received acupuncture at six Feng acpoints by first reinforcement and second reduction,and the control group received oral use of loratadine,10 mg per time,once a day. The treatment lasted 6 weeks. After 6 weeks of treatment,the symptom scores,serum interleukin-4(IL-4),immunoglobulin E(IGE)and interferon gamma(IFN-γ)were compared before and after treatment,and the safety was evaluated. Results(1)During the trial,one case was lost in the treatment group,and one case was lost in the control group. Finally,44 cases in the treatment group and 44 cases in the control group were included in the efficacy statistics.(2)After treatment,the symptom scores of the two groups were significantly improved(P < 0.05),and the improvement in the symptom scores of the treatment group was superior to that of the control group,the difference being statistically significant(P < 0.05).(3)After treatment, the levels of IL-4, IgE and IFN-γ in the two groups were significantly improved(P < 0.05),and the improvement in the levels of IL-4,IgE and IFN-γ of the treatment group was superior to that of the control group(P < 0.05).(4)The total effective rate was 93.18% in the treatment group,and was 75.00% in the control group. The therapeutic effect of the treatment group was superior to that of the control group(P < 0.05).(5)Safety evaluation: The blood pressure and heart rate of the two groups remained stable throughout the study period. One patient in the control group had the symptoms of nausea and poor appetite,and one patient in the treatment group had the symptom of dizziness, but the symptoms did not affect the clinical treatment,and recovered after the treatment was stopped. During the follow-up one month after the treatment,the recurrence rate was 4.55% in the treatment group and 22.73% in the control group. Conclusion Acupuncture at six Feng points by first reinforcement and second reduction can improve the clinical symptoms of pruritus and wind mass in patients with chronic urticaria,and regulate the serum levels of IL-4,IgE and IFN-γ.
作者
谷海燕
赵辉
郝丽君
石志敏
朱叶珊
GU Hai-Yan;ZHAO Hui;HAO Li-Jun;SHI Zhi-Min;ZHU Ye-Shan(Tangshan Hospital of Traditional Chinese Medicine,Tangshan 063000 Hebei,China;Laoting County Hospital,Laoting 063600 Hebei,China;Tangshan Workers Hospital,Tangshan 063000 Hebei,China)
出处
《广州中医药大学学报》
CAS
2020年第6期1072-1076,共5页
Journal of Guangzhou University of Traditional Chinese Medicine
基金
河北省中医药管理局中医药类科研计划课题(编号:2019240)。
关键词
慢性荨麻疹
针刺
阳中隐阴法
治风六穴
免疫炎性因子
chronic urticaria
acupuncture
first reinforcement and second reduction
six Feng points
immune inflammatory factors
作者简介
谷海燕(1981-),女,主管护师,E-mail:zhaohui780613@126.com;通讯作者:石志敏(1978-),男,主任中医师,E-mail:shizhimin_0613@163.com。
