摘要
目的探讨新疆生产建设兵团地区新生儿院内感染类型及血清炎性因子水平变化,并分析新生儿院内感染的病原学特点及影响因素。方法选择2017年5月-2019年1月在本院出生且发生院内感染的新生儿74例为感染组,未发生院内感染的新生儿80例为未感染组,分析胎龄、性别、出生体质量、新生儿窒息、使用抗生素、机械通气、Apgar评分、侵入性操作等与院内感染的关系;检测两组新生儿血清炎性因子水平,并进行比较分析;检测新生儿院内感染的病原菌种类,分析其病原学特点及感染类型。结果感染组新生儿血清炎症因子CRP、IL-6及PCT分别为(21.23±5.09)mg/L、(27.52±10.06)pg/mL和(5.60±1.99)ng/mL,与未感染组的(5.33±2.12)mg/L、(12.13±5.21)pg/mL和(1.11±0.26)ng/mL比较差异均有统计学意义(均P<0.05);74例发生院内感染的新生儿中,呼吸道感染占37.84%,消化道感染占32.43%,血液感染占10.81%。对相关临床资料进行分析,胎龄<37周、新生儿出身体质量<2500g、侵入性操作>3次、新生儿发生窒息、进行机械通气为新生儿发生院内感染的独立危险因素(P<0.05)。结论院内感染的新生儿炎症反应强烈,革兰阴性菌为主要致病菌,感染的发生与新生儿低出生体重、早产及围产期等因素有关,可为临床提供参考。
Objective To explore the type of neonatal nosocomial infection and the change of serum inflammatory factors in Xinjiang Production and Construction Corps(XPCC),and to analyze the pathogenic characteristics and influencing factors of neonatal nosocomial infection.Methods From May 2017 to January 2019,74 neonatal children born in our hospital with nosocomial infection were selected as the infection group.In addition,80 neonates born in our hospital without nosocomial infection were selected as the uninfected group.The clinical data of fetal age,sex,neonatal asphyxia,antibiotics and ventilator were analyzed retrospectively.To investigate the pathogenic characteristics of nosocomial neonatal infection and the changes of blood inflammatory factors in XPCC.To analyze the factors influencing nosocomial infection of newborn in this area.Results The levels of CRP,IL-6 and PCT of infection group is(21.23±5.09)mg/L,(27.52±10.06)pg/mL and(5.60±1.99)ng/mL,the serum levels of CRP,IL-6 and PCT in the uninfected group were(5.33±2.12)mg/L,(12.13±5.21)pg/mL and(1.11±0.26)ng/mL,respectively,the neonatal serum inflammatory factor of infection group is significantly higher than uninfected group(t=39.203,30.354,130.520,P<0.05).Among the 74 newborns with nosocomial infection,respiratory tract,digestive tract,blood is the main type of nosocomial infection,37.84%,32.43%,10.81%respectively.These three infections were 81.08%of all nosocomial neonatal infections.Analyze the relevant clinical data,independent risk factors for nosocomial infection in neonates are gestational age<37 weeks,neonatal body mass<2500 g,invasive operation>3 times,neonatal asphyxia,neonatal amniotic fluid pollution,mechanical ventilation(P<0.05).Conclusion Neonates with nosocomial infections have a strong inflammatory response.Gramnegative bacteria are the main pathogens of nosocomial infection.Nosocomial infection is associated with low birth weight,premature birth and perinatal period.The above information is intended to provide reference for the prevention of nosocomial infection of neonates.
作者
李静
王琳洁
郑丽英
何文英
芦永华
张焱
孙洁
LI Jing;WANG Lin-jie;ZHENG Li-ying;HE Wen-ying;LU Yong-hua;ZHANG Yan;SUN Jie(Hospital Infection ControlOffice,The Firstaffiliated Hospital of Shihezi University Medical College,Shihezi 832008,Xinjiang,China;Changsha Medical College,Changsha 410219,Hunan,China)
出处
《中国病原生物学杂志》
CSCD
北大核心
2020年第3期339-342,共4页
Journal of Pathogen Biology
关键词
新生儿
院内感染
炎症
病原学特点
neonates
nosocomial infection
inflammation
etiological features
作者简介
通讯作者:李静(1974-),女,新疆石河子市人,本科,主管护师,主要从事医院感染方面的研究。E-mail:lj652428@163.com。
