卡马西平、托吡酯、左乙拉西坦联合治疗成人创伤性难治性癫痫患者的疗效与安全性评价被引量：4

Efficacy and Safety of Carbamazepine Combined with Topiramate and Levetiracetam in Treatment of Adult Traumatic Intractable Epilepsy

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摘要目的:探讨卡马西平、托吡酯、左乙拉西坦联合治疗成人创伤性难治性癫痫患者的疗效与安全性。方法:选择2017年7月至2019年7月本院创伤性难治性癫痫患者60例,依据随机数字表法分为两组,对照组30例、观察组30例。对照组给予卡马西平、托吡酯,观察组在此基础上加用左乙拉西坦,比较两组肝功能、癫痫发作情况及不良反应发生.率。结果:治疗后,观察组丙氨酸转氨酶(ALT)、草氨酸转氨酶(AST)水平、癫痫发.作频率及持续时长均较对照组低,差异有统计学意义(P<005);治疗期间,观察组不良反应发生率较对照组略高,但差异无统计学意义(P>005)。结论:卡马西平、托吡酯、左乙拉西坦联合治疗成人创伤性难治性癫痫的效果较好,能改善患者肝功能,降低发作频率及持续时长,且不会明显增加不良反应发生率,较为安全。 Objective: To investigate the efficacy and safety of carbamazepine combined with topiramate and levetiracetam in treatment of adult traumatic intractable epilepsy. Methods: 118 patients with traumatic intractable epilepsy who admitted in the hospital from July 2017 to July 2019 were selected as subjects, and they were divided into control group (30 cases)and observation group(30 cases)according to random number table. Control group was given carbamazepine and topiramate, and observation group was treated with levetiracetam based on control group. The liver function, epileptic seizure and the incidence of adverse reactions were compared between two groups. Results: After treatment, the alanine aminotransferase(ALT), aspartate aminotransferase(AST), frequency and duration of epileptic seizure in observation group were lower than those in control group(P<0.05);The incidence of adverse reactions in observation group was slightly higher than that in control group during the treatment, but the difference was not statistically significant(P>0.05). Conclusion: Carbamazepine combined with topiramate and levetiracetam in treatment of adult traumatic intractable epilepsy have better effects, it can improve liver function, decrease frequency and duration of epileptic seizure, and not increase the incidence of adverse reactions, which is more safe.

作者施升升卢美珍阳清伟陈星宇 SHI Sheng-sheng;LU Mei-zhen;YANG Qing-wei;CHEN Xing-yu(Internal Medicine-Neurology,Zhongshan Hospital Affiliated to Xiamen University,Xiamen Fujian 361000,China;Department of Tumor Radiotherapy,Zhongshan Hospital Affiliated to Xiamen University,Xiamen Fujian 361000,China)

机构地区厦门大学附属中山医院神经内科厦门大学附属中山医院肿瘤放疗科

出处《药品评价》 CAS 2020年第3期5-6,9,共3页 Drug Evaluation

基金 2014年福建省卫计委青年科研课题资助(2014-2-70) 2019年福建省科学技术厅自然基金课题资助(2019J01561)。

关键词卡马西平托吡酯左乙拉西坦成人创伤性难治性癫痫安全性肝功能 Carbamazepine Topiramate Levetiracetam Adult Traumatic Intractable Epilepsy Safety Liver Function

分类号 R742.1 [医药卫生—神经病学与精神病学]

作者简介通讯作者:施升升,博士,主治医师,从事临床诊疗工作。E-mail:sss888208@163.com。