摘要
表没食子儿茶素没食子酸酯(epigallocatechin gallate,EGCG)是从茶叶中分离的多酚类黄酮化合物,具有抗氧化、抗菌、抗肿瘤、降低胆固醇、减肥等生物学功能;但EGCG不稳定的结构及较低的生物利用度限制了其生理功效的发挥。据报道,EGCG经过微生物代谢后,其稳定性、生物利用度明显提高,且大部分代谢产物保留了EGCG原有的生理活性,其中某些生理活性甚至要高于EGCG本身。本文将对微生物介导的EGCG生物转化及其代谢物活性进行综述,重点阐述EGCG代谢产物、代谢途径及代谢物活性,以期为开发EGCG相关的高值化产品及微生物介导多酚转化促进人体健康的深入研究提供理论依据。
Epigallocatechin gallate(EGCG),a polyphenolic flavonoid compound isolated from tea,has many biological functions such as antioxidant,antibacterial,anti-tumor,cholesterol-lowering and anti-obesity properties.However,its instability and low bioavailability lead to limited bioactivities.Recently,biotransformation mediated by microbes may provide an effective way of modifying the structure of EGCG to improve its bioavailability while maintaining and even improving its original bioactivities.This review summarizes the biotransformation of EGCG mediated by different microorganisms and the bioactivities of its resulting breakdown products,mainly focusing on the metabolic pathways,the metabolites,and their bioactivities.It is expected that this review will provides a theoretical basis for further study aiming at the development of EGCG-based value-added products and for in-depth studies on human health promotion triggered by microbial biotransformation of polyphenols.
作者
杜敏如
房倩安
廖振林
方祥
王洁
DU Minru;FANG Qian’an;LIAO Zhenlin;FANG Xiang;WANG Jie(College of Food Science,South China Agricultural University,Guangzhou 510642,China)
出处
《食品科学》
EI
CAS
CSCD
北大核心
2020年第9期204-210,共7页
Food Science
基金
国家自然科学基金青年科学基金项目(31600060)
国家自然科学基金面上项目(31671855)
广州市科技计划项目一般项目专题(201904010274)
广东省科技创新战略专项资金-重点领域研发计划项目(2018B020206001)。
作者简介
第一作者:杜敏如(1988-)(ORCID:0000-0001-5431-9189),女,硕士,研究方向为微生物学。E-mail:466087303@qq.com;通信作者:方祥(1971-)(ORCID:0000-0002-7823-6350),男,教授,博士,研究方向为肠道菌群膳食调控。E-mail:fxiang@scau.edu.cn;通信作者:王洁(1987-)(ORCID:0000-0001-5114-2445),女,副研究员,博士,研究方向为食品微生物、微生物代谢。E-mail:wangjielangjing@126.com。
