摘要
目的探讨降钙素原(PCT)、C-反应蛋白(CRP)、红细胞沉降率(ESR)水平与白细胞(WBC)计数联合检测在呼吸道感染诊断中的价值。方法选取安徽省芜湖市第一人民医院2018年2月~2019年7月呼吸道感染患者共60例为实验组,并根据是否细菌感染分为细菌感染组(33例)和非细菌感染组(27例),另选同期30例健康体检者作为对照组。定量检测并比较各组血清PCT、CRP、ESR及WBC计数水平。结果 PCT、CRP、ESR及WBC计数联合检测时,细菌感染组阳性率显著高于非细菌感染组和对照组,差异有统计学意义(P <0.05)。联合检测时ROC曲线下面积最大,其次是WBC计数、PCT及ESR,CRP最小。各项指标联合检测准确度、灵敏度、特异度均高于单项检测,差异有统计学意义(P <0.05)。结论 PCT、CRP、ESR及WBC计数联合定量检测对呼吸道感染有较高的诊断价值,可以鉴别细菌与非细菌性呼吸道感染,为临床合理用药提供依据。
Objective To explore the value of the combined detection of procalcitonin(PCT), C-reactive protein(CRP),erythrocyte sedimentation rate(ESR) and white blood cell(WBC) count in the diagnosis of respiratory tract infection.Methods From February 2018 to July 2019 in Wuhu NO.1 People′s Hospital, a total of 60 patients with respiratory tract infection were selected as experimental group. According to whether the bacterial infection, they were divided into bacterial infection group(33 cases) and non-bacterial infection group(27 cases). While another 30 healthy subjects were selected as the control group during the same period. The serum PCT, CRP, ESR and WBC count levels of each group were detected quantitatively and compared. Results In the combined detection of PCT, CRP, ESR and WBC counts, the positive rate of the bacterial infection group were significantly higher than those of the nonbacterial infection group and the control group, and the differences were statistically significant(P < 0.05). The area under the ROC curve was the largest during the combined detection, followed by the WBC count, PCT, and ESR, and the CRP was the smallest. The accuracy, sensitivity, and specificity of the combined detection of all indicators were higher than those of the single detection, and the differences were statistically significant(P < 0.05). Conclusion The combined quantitative detection of PCT, CRP, ESR and WBC counts has higher diagnostic value for respiratory infections. It can distinguish bacterial and non-bacterial respiratory infections, and provide a basis for clinical rational drug use.
作者
操金金
崔凡
刘福荣
徐成泉
钱增堃
CAO Jinjin;CUI Fan;LIU Furong;XU Chengquan;QIAN Zengkun(Department of Clinical Laboratory,Wuhu NO.1 People′s Hospital,Anhui Province,Wuhu241000,China)
出处
《中国医药导报》
CAS
2020年第10期161-164,共4页
China Medical Herald
基金
国家高技术研究发展计划(863计划)子课题(2015AA021107)。
关键词
降钙素原
C-反应蛋白
红细胞沉降率
白细胞计数
呼吸道感染
Procalcitonin
C-reactive protein
Erythrocyte sedimentation rate
White blood cell count
Respiratory infection
