摘要
本文应用分子理论,研究中性(A)/聚电解质(B)高分子混合刷对蛋白质的吸附/解吸附特性.理论模型考虑蛋白质与中性高分子A的排斥、以及与聚电解质高分子B的静电吸引.研究发现,在pH=4~6、中性高分子A处于弱水合状态时,混合刷中A高分子链塌缩,B聚电解质链溶胀.由于蛋白质和B聚电解质链间的静电吸引,导致高分子混合刷对蛋白质的吸附.当A高分子水合性增强时,A高分子链溶胀,B聚电解质链塌缩.由于蛋白质与A高分子链间的排斥作用增强,与B聚电解质链间的静电吸引减弱,混合刷对蛋白质解吸附.
Usinga molecular theory,we investigate the mixed neutral(A)/polyelectrolyte(B)polymer brushes with switchable properties toward protein adsorption/desorption.Our model takes repulsion interaction between protein and neutral polymer(A),electrostatic attractive interaction between polyelectrolyte(B)and protein,respectively.We found that in the case of pH=4~6 and weak hydration of polymer A,the A chains adopt a compact conformation on the bottom of the brush while B chains are highly stretched away from the substrate surface.Because of electrostatic attractive interaction between B and protein,protein adsorption occurs.When the hydration of polymer A increases,the inverse transformation of A and B takes place.Because of the increasing repulsion interaction between protein and A and the decreasing electrostatic attractive interaction between B and protein,the proteins can be released by the mixed brushes.
作者
赵新军
李九智
马超
ZHAO Xin-Jun;LI Jiu-Zhi;MA Chao(Xinjiang Laboratory of Phase Transitions and Microstructures of Condensed Matter Physics, Yi Li Normal University, Yining 835000, China;Laboratory of Micro-Nano Electro Biosensors and Bionic Devices, Yi Li Normal University, Yining 835000, China;Department of Urology, the Xinjiang Uygur Autonomous Region People’s Hospital, Urumqi, Xinjiang 830000, China)
出处
《原子与分子物理学报》
CAS
北大核心
2020年第2期177-184,共8页
Journal of Atomic and Molecular Physics
基金
新疆自然科学基金联合基金项目(2019D01C333)。
作者简介
赵新军(1977—),男,副教授,研究方向为软物质的自组织,E-mail:zhaoxinjunzxj@163.com。
