摘要
非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是指除外过量饮酒及其他特异的肝损伤因素、而与代谢综合征和胰岛素抵抗有关的肝细胞内过多脂肪沉积性疾病,是目前全世界最常见的肝脏疾病之一,且发病率呈逐年上升趋势。随病情进展,NAFLD患者可发生非酒精性脂肪肝炎(nonalcoholic steatohepatitis,NASH)、肝硬化和肝细胞性肝癌。肝纤维化的发生与程度是影响NAFLD预后的关键因素,因此对NAFLD患者及时发现、评估和治疗肝纤维化非常重要。现对NAFLD肝纤维化的发生机制、诊断及治疗进行概述。
Nonalcoholic fatty liver disease(NAFLD)refers to excessive excess fat deposition in the liver in theabsence of excessive alcohol consumption and other specific liver damage factors,which is associated with metabol-ic syndrome and insulin resistance.It is one of the most common liver diseases worldwide and has an increasing inci-dence.With disease progression,NAFLD patients may develop nonalcoholic steatohepatitis(NASH),liver cirrho-sis,and hepatocellular carcinoma.The development and severity of liver fibrosis is a key prognostc factor forNAFLD,and it is very important for NAFLD patients to early evaluate,dagnose,and treat liver fibrosis.This reviewsummarizes the pathogenesis,diagnosis,and treatment of liver fibrosis in patients with NAFLD.
作者
魏倩(综述)
郭津生(审校)
WEI Qian;GUO Jinsheng(Department of Gastroenterology and Hapatology,Zhong Shan Hospital,Fudan University,Shanghai Institute of Liver Diseases,Shanghai,200032,China)
出处
《西南医科大学学报》
2020年第2期97-102,共6页
Journal of Southwest Medical University
关键词
非酒精性脂肪肝病
肝纤维化
发生机制
诊断
治疗
Nonalcoholic fatty liver disease
Liver fibrosis
Pathogenesis
Diagnosis
Treatment
作者简介
第一作者:魏倩,住院医师,硕士;通信作者:郭津生,主任医师,博士。Email:guo.jinsheng@zs-hospital.sh.cn。
