摘要
目的:探讨妊娠合并地中海贫血孕妇血红蛋白(HGB)、血清铁蛋白(SF)变化及对母婴结局影响。方法:选取2017年12月-2018年12月本院收治的妊娠合并地中海贫血患者67例为观察组,同期本院体检正常的67例妊娠期妇女为对照组。比较两组各孕期HGB、SF变化及母婴结局。结果:对照组各孕期HGB变化高于观察组且下降幅度(15.8±0.4 g/L)小于观察组(28.9±1.6 g/L)(P<0.05);两组孕早期SF变化无差异(P>0.05),对照组孕中晚期SF变化高于观察组且下降幅度(75.5±5.2 ng/ml)小于观察组(81.9±6.9 ng/ml)(P<0.05),母婴不良结局发生低于观察组(P<0.05)。结论:妊娠合并地中海贫血的患者HGB在妊娠各期均出现不同程度的降低,SF在妊娠中期及晚期存在不同程度的降低,同时能对母婴结局产生不良影响。
Objective:To investigate the changes of the hemoglobin(HGB)value and serum ferritin(SF)level of pregnant women with thalassemia,and to study their influence on maternal and infant outcomes.Methods:67 pregnant women with thalassemia from December 2017 to December 2018 were selected in study group,and 67 normal pregnant women were selected in control group during the same period.The changes of HGB value and SF level of women during pregnancy,and maternal and infant outcomes of women were compared between the two groups.Results:The change of HGB value of women in the study group during different pregnant period was significant more than that of women in the control group,and the degree of decreased of HGB value of women in the study group during pregnancy was 15.8±0.4 g/L,which was significant less than that(28.9±1.6 g/L)of women in the control group(P<0.05).There was no significant difference in the change of SF level of women during the first trimester pregnancy between the two groups(P>0.05).The degree of decreased of SF level of women during the second and third trimester pregnancy in the study group was 75.5±5.2 ng/ml,which was significant less than that(81.9±6.9 ng/ml)of women in the control group(P<0.05).The rate of maternal and infant adverse outcomes in the study group was significant lower than that of women in the control group(P<0.05).Conclusion:HGB value of women with thalassemia during different pregnant period decreases to different degrees,and their SF level decreases to different degrees during the second and third trimester of pregnancy,both the decreasing of HGB value and SF level of women during pregnancy have adverse effects on maternal and infant outcomes.
作者
黎丽嫦
张海花
班正贺
LI Lichang;ZHANG Haihua;BAN Zhenghe(Guangzhou Baiyun Maternal and Child Health Care Hospital, Guangdong Province,510410)
出处
《中国计划生育学杂志》
2020年第3期446-448,共3页
Chinese Journal of Family Planning
关键词
地中海贫血
妊娠
血红蛋白
血清铁蛋白
母婴结局
Thalassemia
Pregnancy
Hemoglobin
Serum ferritin
Maternal and infant outcomes
