摘要
目的评估胶原抗菌敷料治疗烧伤后残余创面的疗效及安全性.方法2012年1月至2016年11月符合要求的烧伤患者99例(200个残余创面).根据患者意愿,48例(100个残余创面)患者给予胶原抗菌敷料联合浸浴疗法为胶原抗菌敷料组(观察组),51例(100个残余创面)患者给予碘伏液联合浸浴疗法为碘伏组(对照组).观察周期为20d或创面完全愈合日,比较两组患者创面愈合时间、创面愈合率、创周皮炎症状的改善情况、创面治疗显效率及创面细菌检出情况,统计不良事件的发生.结果观察组创面愈合时间(13±6)d,较对照组(16±7)d明显缩短(P=0.001).观察组用药后第7、14、20天创面愈合率分别为[55(31,87)]%、[100(81,100)]%、[100(100,100)]%,高于对照组的[25(40,85)]%,[100(75,100)]%,[100(90,100)]%,(Z=1.766、1.995、4.041,P=0.077、0.046、0.000).观察组用药前、用药后第3天创周皮炎指标评分分别为7(6,8)分、6(5,7)分,对照组为7(6,8)分、6(6,8)分,差异无统计学意义.(Z=1.619、1.375,P=0.105、0.169).观察组用药后第7天创周皮炎指标评分为3(2,4)分,低于对照组4(3,5)分(Z=4.152,P=0.000).观察组治疗总显效率(85%)比对照组(70%)明显提高(χ^2=6.452,P=0.011).两组创面换药过程中,观察组检出细菌7株,对照组检出细菌20株,组间比较差异有统计学意义(χ^2=7.236,P=0.007).用药后两组患者均未见明显不良反应.结论胶原抗菌敷料具有抗菌功效,可以促进烧伤后残余创面的愈合,改善创周的皮炎症状.
Objective To evaluate the effect and safety of collagen antibacterial dressing for the management of residual burn wounds.Methods A study was performed for 99 patients(200 residual burn wounds)who met requirements from January 2012 to November 2016 in burn department.They were divided into two groups according to patients5 preference.Collagen antibacterial dressing and immersion therapy were applied in one group,iodine and immersion therapy were applied in another group.The healing time was observed up to 20 days or wound healing.A comparison of wound healing time,wound healing rate,dermatitis,effective rate of the wound and infection was done between the two groups.The adverse events were also observed.The Chi-square test,Student t test,Mann-Whitney U test,Logrank test were performed to assess.Results The wound healing time was much more shorter in collagen antibacterial dressing group((13±6)days vs(16±7)days,P=0.001).The wound healing rate after treatment in collagen antibacterial dressing group was larger than immersion group at the 7th,14th and 20th day[55(31,87)%,100(81,100)%,100(100,100)%vs 25(40,85)%,100(75,100)%,100(90,100%),(Z=1.766,1.995,4.041,P=0.077,0.046,0.000)].The score of dermatitis in collagen antibacterial dressing group was no significant difference before treatment and the 3th day after treatment[7(6,8),6(5,7)vs7(6,8),6(6,8),Z=1.619,1.375,P=0.105,0.169)].The score of dermatitis in collagen antibacterial dressing group was lower than immersion group at the 7th day[3(2-4)vs 4(3-5),Z=4.152,p=0.000].The total effective rate of the wound in trial group was higher(85%vs 70%,x^2=6.452,P=0.011).7 strains of bacteria were isolated in collagen antibacterial dressing group,20 strains were isolated in iodine group,there was significant difference(X^2=7.236,P=0.007).No adverse events were observed in the two group during the study.Conclusions Collagen antibacterial dressing has the function of anti-infection,promotes the healing of residual burn wounds,and relieves the dermatitis.
出处
《浙江临床医学》
2020年第3期393-396,共4页
Zhejiang Clinical Medical Journal
基金
浙江省温州市科技计划项目(Y20160328)。
关键词
胶原抗菌敷料
烧伤
残余创面
浸浴
Collagen antibacterial dressing
Bum
Residual bum wounds
Immersion therapy
作者简介
通信作者:林才。
