摘要
获得性免疫缺陷综合征和慢性乙型肝炎是世界范围内广泛关注的两大传染性疾病,至今尚无有效的治愈方法。由于两者存在相同的传播途径,人类免疫缺陷病毒/乙型肝炎病毒(HIV/HBV)共感染患者在临床上较为常见。近年来,有效抗反转录病毒疗法的普及显著降低了HIV感染者的发病率和病死率,延长了HIV感染者的寿命。但HIV/HBV共感染者肝脏相关疾病的病死率仍显著高于单纯HIV感染患者。HIV可影响HBV感染的自然史,与单纯HBV感染相比,HIV/HBV共感染引起HBV-DNA水平升高、肝脏疾病进展加快及肝脏相关疾病病死率增高得到广泛认同。
Acquired immune deficiency syndrome and chronic hepatitis B are two infectious diseases that have attracted worldwide attention,which still have no effective cures.Because they share the same transmission route,human immunoodeficiency virus(HIV)/hepatitis B virus(HBV)co-infection is more common in clinical practice.In recent years,the popula-rity of effective antiretroviral therapy has significantly reduced the morbidity and mortality of HIV-infected population and extended their life span.However,the mortality rate of liver related diseases in patients with HIV/HBV infection is still significantly higher than that of patients with HIV infection alone.HIV can affect the natural history of HBV infection.Compared with HBV infection alone,co-infection with HIV/HBV has been widely recognized to cause increased HBV-DNA levels,accelerated progression of liver disease,and increased mortality from liver-related diseases.
作者
刘思宇
王福祥
陈晓红
LIU Siyu;WANG Fuxiang;CHEN Xiaohong(Department of Infectious Diseases,the Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China;Department of Infectious Diseases,Shenzhen Third People′s Hospital,Shenzhen 518000,China)
出处
《医学综述》
2020年第8期1472-1476,共5页
Medical Recapitulate
基金
国家自然科学基金(81672003)
黑龙江省自然科学基金(C2017043)
“十三五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2017ZX10202102-004-001,2018ZX10302104-001-005)
黑龙江省自然科学基金青年基金(QC2016110)。
作者简介
通信作者:陈晓红,Email:catherine89034@163.com。
