摘要
目的研究老年重症细菌性肺炎患者抗生素相关性腹泻的临床特征与治疗策略。方法方便选择使用抗生素后引起相关性腹泻的老年重症细菌性肺炎患者40例作为研究对象,收取时间在2018年1月-2019年1月,随机分两组,其中观察组实施益生菌制剂治疗;对照组实施常规治疗,分析两组治疗效果、不同时间段菌群及相关性腹泻、营养情况和住院时间。结果观察组老年患者治疗总有效率95.00%高于对照组,差异有统计学意义(χ~2=4.329,P<0.05)。治疗后15 d,观察组老年患者大肠杆菌数量、乳酸菌、双岐杆菌数量均低于对照组,差异有统计学意义(t=3.414,5.117,3.186,P<0.05)。观察组老年患者出现腹泻时间(7.12±1.02)d长于对照组出现腹泻时间、腹泻持续时间短于对照组,差异有统计学意义(P<0.05)。观察组老年患者白蛋白水平、总蛋白水平、住院时间短于对照组,差异有统计学意义(P<0.05)。结论在使用抗生素后引起相关性腹泻的老年重症细菌性肺炎患者中,肠道内有益菌均伴有不同程度减少,通过应用益生菌制剂治疗,纠正肠道菌群失调,对治疗抗生素相关性腹泻具有显著效果。
Objective To study the clinical characteristics and treatment strategies of antibiotic-associated diarrhea in elderly patients with severe bacterial pneumonia. Methods Forty elderly patients convenient selection with severe bacterial pneumonia caused by antibiotic use were selected as the study subjects. They were collected from January 2018 to January2019. They were randomLy divided into two groups. The observation group was treated with probiotics, while the control group was treated with routine treatment. The therapeutic effect, bacterial flora and related diarrhea, nutritional status and hospitalization time of the two groups were analyzed. Results The total effective rate of the observation group was 95.00%higher than that of the control group,the difference was statistically significant(χ~2=4.329,P<0.05). There was a significant difference between the two groups. 15 d after treatment, the number of E.coli,Lactobacillus and Bifidobacterium in the observation group was lower than that in the control group,the difference was statistically significant(t=3.414,5.117,3.186,P<0.05). The duration of diarrhea in the observation group was longer than that in the control group(7.12±1.02)d, and the duration of diarrhea was shorter than that in the control group,the difference was statistically significant(P<0.05). The albumin level, total protein level and hospitalization time in the observation group were shorter than those in the control group,the difference was statistically significant(P<0.05). Conclusion In the elderly patients with severe bacterial pneumonia caused by antibiotic use, the beneficial bacteria in intestinal tract are reduced in varying degrees. The application of probiotics to correct intestinal flora imbalance has a significant effect on the treatment of antibiotic-related diarrhea.
作者
刘轶
LIU Yi(Department of Critical Care Medicine,Changzhou Traditional Chinese Medicine Hospital,Changzhou,Jiangsu Province,213000 China)
出处
《中外医疗》
2020年第3期49-51,共3页
China & Foreign Medical Treatment
关键词
老年重症细菌性肺炎
抗生素相关性腹泻
临床特征
治疗策略
Senile severe bacterial pneumonia
Antibiotic-associated diarrhea
Clinical characteristics
Therapeutic strategies
作者简介
刘轶(1981-),男,江苏常州人,本科,副主任医师,研究方向:重症医学。
