摘要
目的探讨依达拉奉联合瑞舒伐他汀对脑梗死患者炎性因子和神经功能的影响。方法选取2018年3月至2019年7月我院收治的96例脑梗死患者作为研究对象,按照随机数字表法将其分为对照组和观察组,每组48例。对照组给予依达拉奉治疗,观察组给予依达拉奉联合瑞舒伐他汀治疗。比较两组的治疗效果。结果观察组的治疗总有效率明显高于对照组(P<0.05)。治疗后,两组的Cys-C、Hcy、IL-6、TNF-α、hs-CRP及MMP-9水平均明显降低,且观察组显著低于对照组(P<0.05)。治疗后,两组的SOD、GSH-Px、CAT水平均显著升高,MDA水平显著降低,且观察组优于对照组(P<0.05)。治疗后,两组的CSS评分显著降低,且观察组显著低于对照组(P<0.05)。结论依达拉奉联合瑞舒伐他汀治疗脑梗死的效果确切,能够有效控制患者病情发展,明显改善患者体内炎性因子和氧化应激水平,对患者神经功能恢复有积极的影响作用。
Objective To explore the effect of edaravone combined with rosuvastatin on inflammatory factors and neurological function in patients with cerebral infarction.Methods Ninety-six patients with cerebral infarction admitted in our hospital from March 2018 to July 2019 were selected as the study objects,and the patients were divided into control group and observation group according to the random number table method,with 48 cases in each group.The control group was treated with edaravone,and the observation group was treated with edaravone combined with rosuvastatin.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the levels of Cys-C,Hcy,IL-6,TNF-α,hs-CRP and MMP-9 in the two groups significantly decreased,and those in the observation group were significantly lower than the control group(P<0.05).After treatment,the levels of SOD,GSH-Px,CAT in the two groups significantly increased,and the levels of MDA significantly decreased,and those in the observation group were better than the control group(P<0.05).After treatment,the score of CSS in the two groups significantly decreased,and that in the observation group was significantly lower than the control group(P<0.05).Conclusion Edaravone combined with rosuvastatin is effective in the treatment of cerebral infarction.It can effectively control the development of patients'condition,significantly improve the levels of inflammatory factors and oxidative stress in patients,and has a positive impact on the recovery of neurological function.
作者
李红发
崔亚军
LI Hong-fa;CUI Ya-jun(the People's Hospital of Qianyang County,Baoji 721100;Traditional Chinese Medicine Hospital of Fengxiang County,Baoji 721400,China)
出处
《临床医学研究与实践》
2020年第9期36-38,共3页
Clinical Research and Practice
关键词
依达拉奉
瑞舒伐他汀
脑梗死
炎性因子
神经功能
edaravone
rosuvastatin
cerebral infarction
inflammatory factors
neurological function
作者简介
李红发(1976-),男,汉族,陕西千阳人,主治医师,学士。研究方向:脑梗死、脑出血相关疾病;通讯作者:崔亚军,E-mail:739402520@qq.com.
