摘要
骨性关节炎(OA)是一种以关节软骨进行性退化为特征的骨关节疾病,是中老年人常见疾病之一。随着我国老龄化现象加重,预计到2020年OA将会成为第四大致残性疾病。OA主要引起疼痛、僵硬和移动困难,导致进行性残疾,给患者带来极大痛苦,但目前其发病机制尚不清楚。软骨细胞是关节软骨中的唯一细胞,其死亡在OA发展中起重要作用。软骨细胞死亡的方式有凋亡、自噬性细胞死亡和坏死性细胞死亡三种,三者存在密切联系。探究软骨细胞在OA中的死亡方式可为OA的预后提供新思路。
Osteoarthritis(OA)is a bone and joint disease characterized by progressive cartilage degradation and it is a common disease in the elderly population.With the aging aggravation in China,OA is expected to become the fourth major disabling disease by 2020.OA mainly causes pain,stiffness and difficulty in movement,which leads to progressive disability and great pain of the patients.However,the detailed pathogenesis of OA has not yet been elucidated.Chondrocytes are the only cells in articular cartilage,and their death plays an important role in the development of OA.Chondrocyte death manners consist of apoptosis,autophagy and necrosis,which are closely associated.By exploring the death mode of chondrocytes in OA,it will provide a new way for the prognosis of OA.
作者
姜思羽
许碧莲
刘义
JIANG Siyu;XU Bilian;LIU Yi(Department of Pharmacology,Guangdong Medical University,Zhanjiang 524023,China;Guangdong Key Laboratory for Research and Development of Natural Drugs,Guangdong Medical University,Zhanjiang 524023,China;Marine Medicine Research Institute,Guangdong Medical University,Zhanjiang 524023,China)
出处
《医学综述》
2020年第7期1254-1258,共5页
Medical Recapitulate
基金
国家自然科学基金(81373499)。
关键词
骨性关节炎
软骨细胞
凋亡
自噬
坏死
Osteoarthritis
Chondrocyte
Apoptosis
Autophagy
Necrosis
作者简介
通信作者:许碧莲,Email:gdmcxu@126.com。
