摘要
目的研究羟考酮和帕瑞昔布钠对鼻内镜手术患者干预效果,为临床应用提供数据参考。方法选取2016年4月-2018年4月在丽水市人民医院就诊的鼻内镜手术患者80例,采用数字随机法分为帕瑞昔布钠组和联合组,每组40例。帕瑞昔布钠组麻醉诱导前30 min给予帕瑞昔布钠(40 mg);联合组在帕瑞昔布钠组基础上给予羟考酮(10 mg)。统计进入手术室时(T0)、手术结束时(T1)、拔管结束时(T2)、出手术室时(T3)各项指标。结果 T3时间段,联合组HR[(61.75±12.18)次/min]、SBP[(106.62±10.63)mm Hg,1 mm Hg=0.133 kPa]、DBP[(66.62±8.15)mm Hg]、SPO2[(94.89±0.84)%]、IL-2[(15.16±1.92)pg/L]、IL-4[(20.12±2.22)pg/L]、IL-5[(42.86±2.82)pg/L]、[IL-17(3.51±1.16)pg/L]低于帕瑞昔布钠组HR[(79.45±10.15)次/min、SBP(124.86±11.45)mm Hg、DBP(76.62±8.96)mm Hg、SPO2(98.78±1.26)%、IL-2(21.45±2.10)pg/L、IL-4(29.26±2.45)pg/L、IL-5(48.98±3.89)pg/L、IL-17(5.95±1.31)pg/L,均P<0.001]。联合组患者躁动评分、VAS评分、拔管时间均低于帕瑞昔布钠组(均P<0.05)。结论羟考酮联合帕瑞昔布钠能减少患者麻醉苏醒期躁动,改善患者术后疼痛、血清炎性因子水平。
Objective To study the intervention effect of oxycodone and parecoxib sodium on patients undergoing nasal endoscopic surgery, and to provide data reference for clinical application. Methods Eighty patients who underwent endoscopic sinus surgery in our hospital from April 2016 to April 2018 were selected and randomly divided into parecoxib sodium group and combined group with 40 cases in each group. The parecoxib sodium group was given parecoxib sodium(40 mg) 30 minutes before induction of anesthesia, and the combined group was given oxycodone(10 mg) on the basis of parecoxib sodium group. The indexes of entering the operating room(T0), at the end of operation(T1), at the end of extubation(T2), and when leaving the operating room(T3) were counted. Results In the T3 period, HR(61.75±12.18) times/min, SBP(106.62±10.63) mm Hg, DBP(66.62±8.15) mm Hg, SPO2(94.89±0.84) %, IL-2(15.16±1.92) pg/L, IL-4(20.12±2.22) pg/L, IL-5(42.86±2.82) pg/L, and IL-17(3.51±1.16) pg/L of the combined group were lower than those of the parecoxib group(79.45±10.15) times/min,(124.86±11.45),(76.62±8.96) mmHg,(98.78±1.26) %,(21.45±2.10),(29.26±2.45),(48.98±3.89),(5.95±1.31) pg/L(all P<0.001). The score of agitation, VAS score and extubation time in the combined group were lower than those in the parecoxib group(all P<0.05). Conclusion Oxycodone combined with parecoxib sodium can reduce restlessness during anesthesia recovery, improve pain and serum inflammatory factors levels.
作者
王伟娟
刘英
戴仁锋
王昌雄
陈伟康
WANG Wei-juan;LIU Ying;DAI Ren-feng;WANG Chang-xiong;CHEN Wei-kang(Department of Anesthesiology,Lishui People's Hospital,Lishui,Zhejiang 323000,China)
出处
《中华全科医学》
2020年第3期388-391,共4页
Chinese Journal of General Practice
基金
浙江省医药卫生科技计划项目(2018KY925)。
关键词
羟考酮
帕瑞昔布钠
鼻内镜手术
Oxycodone
Parecoxib sodium
Nasal endoscopic surgery
作者简介
通信作者:王伟娟,E-mail:wensheng8202@163.com。
