摘要
目的观察雷公藤多苷联合多西环素治疗掌跖脓疱病的疗效.方法选取长治市第二人民医院2014年6月至2017年11月治疗的掌跖脓疱病患者144例的临床资料进行回顾性分析,根据治疗方法的不同分为三组,每组48例.多西环素组采用多西环素治疗,雷公藤多苷组使用雷公藤多苷治疗,联合用药组采用雷公藤多苷联合多西环素治疗.比较三组患者的临床症状下降指数(SSRI)、临床效果、外周血T淋巴细胞亚群变化情况.结果联合用药组脓疱、红斑、痂屑、瘙痒SSRI改善率分别为95.83%(46/48)、93.75%(45/48)、97.92%(47/48)、93.75%(45/48),与多西环素组[72.92%(35/48)、70.83%(34/48)、75.00%(36/48)、77.08%(37/48)]、雷公藤多苷组[83.33%(40/48)、81.25%(39/48)、85.42%(41/48)、89.58%(43/48)]差异均有统计学意义(x2=9.417、8.542、10.568、6.306,均P<0.05);联合用药组总有效率[95.83%(46/48)]高于多西环素组[66.67%(33/48)]、雷公藤多苷组[81.25%(39/48)](x2=5.285,P<0.05;x2=1.771,P=0.076);三组CD4+、CD8+、CD4+/CD8+差异均有统计学意义(F=3.854、4.856、5.019,P=0.017、0.024、0.030).结论雷公藤多苷联合多西环素治疗掌跖脓疱病,能改善患者的临床症状和T淋巴细胞免疫功能,提高临床疗效.
Objective To study the efficacy of Tripterygium wilfordii polyglycosides combined with doxycycline in the treatment of palmoplantar pustulosis.Methods From June 2014 to November 2017,144 patients with palmoplantar pustulosis treated in the Second People s Hospital of Changzhi were selected and divided into three groups according to different treatment methods,with 48 cases in each group.The doxycycline group was treated with doxycycline.The Tri pterygium wilfordii polyglycosides group was treated with Tripterygium wilfordii poly glycosides.The combination group was treated with Tripterygium wilfordii polyglycosides combined with doxycycline.The symptom score decline index(SSRI),clinical effect and changes of T lymphocyte subsets in peripheral blood were compared among three groups.Results The SSRI improvement rates of pustule,erythema,scab and pruritus in the combination group were 95.83%(46/48),93.75%(45/48),97.92%(47/48),97.92%(47/48),respectively,which were higher than those in the doxycycline group[72.92%(35/48),70.83%(34/48),75.00%(36/48),77.08%(37/48)]and the Tripterygium wilfordii polyglycosides group[83.33%(40/48),81.25%(39/48),85.42%(41/48),89.58%(43/48)],the differences were statistically significant(X2=9.417,8.542,10.568,6.306,all P<0.05).The total effective rate of the combination group was 95.83%(46/48),which was higher than that of the doxycycline group[66.67%(33/48)]and the Tripterygium wilfordii polyglycoside group[81.25%(39/48)](X2=5.285,P<0.05;X2=1.771,P=0.076).There were statistically significant differences in CD4+,CD4+,CD4+/CD4+among the three groups(F=3.854,4.856,5.019,P=0.017,0.024,0.030).Conclusion Tripterygium wilfordii polyglycoside combined with doxycycline can improve the clinical symptoms and T lymphocyte immune function in patients with palmoplantar pustulosis.
作者
朱秀兰
Zhu Xiulan(Department of Dermatology,the Second People's Hospital of Changzhi,Changzhi,Shanxi 046000,China)
出处
《中国基层医药》
CAS
2020年第4期433-436,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
山西省卫生和计划生育委员会中医科研课题(2014ZY07)。
关键词
皮肤疾病
丘疹鳞屑性
银屑病
雷公藤多苷
多西环素
药物疗法
联合
T淋巴细胞
治疗结果
临床对照试验
Skin diseases,papulosquamous
Psoriasis
Tripterygium wilfordii polyglycosides
Doxycycline
Drug therapy,combination
T-Lymphocytes
Treatment outcome
Controlled clinical trial
