摘要
哺乳动物个体由终端分化的单倍体精子和卵子受精融合成的双倍体受精卵发育而来。在胚胎发育的初始阶段,合子基因组处于休眠状态,胚胎发育调控由卵母细胞内母源调控逐渐转换为合子基因组调控(Maternal-Zygotic Transition,MZT)。在此期间,随着母源物质的清除,合子基因组激活(Zygotic Genome Activation,ZGA),但调控MZT的具体分子机制还不清楚。最新研究表明,DNA甲基化、染色质重塑、组蛋白表观修饰、ncRNA在MZT和ZGA中发挥重要的作用。本文总结了上述4种表观修饰在动物植入前胚胎MZT中的生物学功能和特异的分子机制,对揭示动物胚胎MZT的调控机理有借鉴意义。
Mammalian individuals develop from diploid fertilized eggs,which are formed by terminally differentiated haploid sperm and egg fertilization.In the initial stage of embryonic development,the zygote genome is dormant,and the regulation of embryonic development is gradually transformed from maternal regulation in oocytes to zygotic transition(MZT).During this period,the zygote genome activation(ZGA)is activated with the clearance of maternal material,but the specific molecular mechanism regulating MZT is still unclear.Recent studies have shown that DNA methylation,chromatin remodeling,histone epigenetic modification and ncRNA play important roles in MZT and ZGA.This paper summarizes the biological functions and specific molecular mechanisms of the above four apparent modifications in MZT of preimplantation embryos,which can be used for reference to reveal the regulatory mechanism of MZT of animal embryos.
作者
张颖
李晓霞
许保增
ZHANG Ying;LI Xiaoxia;XU Baozeng(Institute of Special Animal and Plant Sciences,Chinese Academy of Agricultural Science,Jilin Changchun 130112,China;Stake Key Laboratory For Molecular Biology of Special Economic Animal and Plant Science,Chinese Academy of Agricultural Science,Jilin Changchun 130112,China)
出处
《中国畜牧杂志》
CAS
北大核心
2020年第3期1-6,共6页
Chinese Journal of Animal Science
基金
国家自然科学基金面上项目(31772606)
吉林省国际科技合作项目(20170414049GH)
中国农业科学院科技创新工程(CAAS-ASTIP-2018-ISAPS)
中国农业科学院科技创新工程协同创新(CAAS-XTCX2016010-02)。
作者简介
张颖(1994-),女,辽宁铁岭人,硕士,研究实习员,研究方向为动物胚胎工程,E-mail:zhangying85984@163.com;通讯作者:李晓霞(1980-),女,吉林白山人,博士,副研究员,研究方向为动物遗传育种与繁殖,E-mail:lixiaoxia_dyf@sina.com;通讯作者:许保增(1980-),男,河北邯郸人,博士,研究员,研究方向为特种经济动物繁殖,E-mail:xubaozeng@caas.cn。
