摘要
目的比较黄体期长效长方案、黄体期短效长方案及卵泡期长效长方案3种不同降调节方案在体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)中的治疗结局。方法回顾性分析2015~2018年在郑州大学第二附属医院行IVF-ET治疗的5 427例患者的临床资料,根据促排卵方案的不同分为3组,其中A组黄体期长效长方案(207例),B组黄体期短效长方案(4 230例),C组卵泡期长效长方案(990例),比较3种方案的促性腺激素(gonadotropins,Gn)用量、Gn天数、获卵数、MII(Metaphase II)卵数、优质胚胎数、MII卵率、优质胚胎率、胚胎着床率、临床妊娠率、异位妊娠率、早期流产率。结果①B组患者Gn用量、Gn天数、获卵数、MII卵数均小于A组与C组,差异有统计学意义(P<0.01);②优质胚胎率C组>B组>A组,差异有统计学意义(P<0.01);③胚胎着床率、临床妊娠率C组>A组>B组,差异有统计学意义(P<0.01);④3组间异位妊娠率、早期流产率比较差异无统计学意义(P>0.01)。结论卵泡期长效长方案优胚率与短效长方案相近,且卵泡期长效长方案胚胎着床率及临床妊娠率高于黄体期长效长方案及短效长方案。
Objective To compare the outcome of different ovulation promotion protocols in vitro fertilization and embryo transfer(IVF-ET).Methods Retrospective analyze the clinical data of 5 427 patients receiving IVF-ET in the Second Affiliated Hospital of Zhengzhou University from 2015 to 2018.According to the different ovulation promotion protocols, they were divided into three groups: group A of 207 cases for luteal phase short-acting long-term plan, group B of 4 230 cases for luteal phase short-acting long-term plan, and group C of 990 cases for long-term follicular phase plan.The Gn dosage, Gn days, number of eggs obtained, high quality embryo rate, implantation rate, clinical pregnancy rate,ectopic pregnancy rate and abortion rate of the three groups were observed.Results ① The Gn dosage, Gn days, number of eggs obtained and number of MII eggs in group B were less than those in group A and group C, and the differences were statistically significant(P<0.01).② The high quality embryo rate in group C was higher than that in group B and group A, group A higher than grong B,and the difference was statistically significant(P<0.01).③ Implantation rate and clinical pregnancy rate in group C were higher than those in group A and group B, group A higher than grong B,and the differences were statistically significant(P<0.01).④ There were no significant differences in ectopic pregnancy rate and early abortion rate among the three groups(P>0.01).Conclusion The optimal embryo rate of long-term follicular phase protocol was similar to that of short-term plan, and the implantation rate and clinical pregnancy rate were higher than that of lower regulation protocol in luteal phase.
作者
郭沛沛
谭丽
GUO Pei-pei;TAN Li(Department of Reproductive Medicine,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou Henan 450000,P.R.China)
出处
《中国计划生育和妇产科》
2020年第3期67-69,共3页
Chinese Journal of Family Planning & Gynecotokology
作者简介
郭沛沛,毕业于郑州大学,硕士,医师,主要研究方向为生殖内分泌;通讯作者:谭丽,E-mail:litan668@126.com。
