摘要
骨骼肌是胰岛素介导的葡萄糖摄取、代谢、利用的主要靶器官之一,也是IR发生最早和最重要的部位。骨骼肌中线粒体、NOX、一氧化氮合酶、血管紧张素Ⅱ均可产生活性氧,骨骼肌IR与活性氧密切相关。研究表明,生理水平的活性氧有助于维持骨骼肌IS,而过量的活性氧通过损害线粒体结构与功能、IS及葡萄糖摄取导致骨骼肌IR。另外,运动是改善糖尿病的有效手段,可通过调控抗氧化酶活性及HSP72的表达改善骨骼肌IR。
Skeletal muscle is one of the major target organs of insulin-mediated glucose uptake,metabolism and utilization,and it is the earliest and most important site of insulin resistance(IR).Mitochondria,NOX,nitric oxide synthase and angiotensin Ⅱ in skeletal muscle can produce reactive oxygen species,which is closely related to IR in skeletal muscle.Studies have shown that physiological levels of reactive oxygen species help maintain skeletal muscle insulin sensitivity,while excess reactive oxygen species cause IR in skeletal muscle by impairing mitochondrial structure and function,insulin sensitivity(IS),and glucose uptake.In addition,exercise is an effective way to improve diabetes,which may improve IR in skeletal muscle by regulating antioxidant enzyme activity and HSP72 expression.
作者
郑莉芳
陈佩杰
肖卫华
ZHENG Lifang;CHEN Peijie;XIAO Weihua(School of Kinesiology,Shanghai University of Sports,Shanghai 200438,China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2020年第2期153-157,共5页
Chinese Journal of Diabetes
基金
国家自然科学基金(31271273、31300975)
上海市自然科学基金(18ZR1437100)
上海市人类运动能力开发与保障重点实验室(上海体育学院)(11DZ2261100)。
关键词
活性氧
骨骼肌
胰岛素抵抗
运动
Reactive oxygen species:Skeletal muscle:Insulin resistance
Exercise
作者简介
通信作者:肖卫华,Email:xiaoweihua@sus.edu.cn。
