摘要
右美托咪定作为一种高选择性α2肾上腺素能受体激动剂,具有镇静、镇痛和减轻应激反应等作用。大量的研究证实,围术期应用右美托咪定,不但具有辅助镇痛作用,还可减少其他镇痛药物的用量,减轻其不良反应,增强其镇痛效果,从而提高患者围术期的舒适度,保持血流动力学稳定,减少术后疼痛反应。该文就右美托咪定应用于围术期镇痛的研究进展进行综合阐述。
Dexmedetomidine,as a highly selective 2 adrenergic receptor agonist,has sedative,analgesic and stress-relieving effects. A large number of studies have confirmed that the perioperative application of dexmedetomidine not only has an auxiliary analgesic effect,but also can reduce the dosage of other analgesic drugs,reduce its adverse reactions,and enhance its analgesic effect,so as to improve the perioperative comfort of patients,maintain hemodynamic stability,and reduce postoperative pain. This article reviews the action mechanism of dexmedetomidine and the effect of dexmedetomidine on perioperative analgesia.
作者
刘璇
滕金亮
LIU Xuan;TENG Jin-liang
出处
《神经药理学报》
2019年第6期41-46,共6页
Acta Neuropharmacologica
关键词
右美托咪定
围术期
镇痛
dexmedetomidine
perioperative
analgesic
作者简介
通讯作者:滕金亮,主任医师,研究生导师。
