摘要
目的建立乌鲁木齐市健康人群胆红素参考区间,探讨汉族和维吾尔族健康人群胆红素水平的差异。方法通过乌鲁木齐市体检者问卷调查结果和实验室检查结果筛选出健康人群5478例,回顾性分析和比较胆红素水平,分析汉族和维吾尔族健康人群胆红素分布特点。结果乌鲁木齐市健康人群胆红素参考区间:总胆红素男性6.45~29.57μmol/L、女性5.62~25.29μmol/L,直接胆红素男性1.50~12.07μmol/L、女性1.05~8.62μmol/L;该参考区间高于《全国临床检验操作规程》(第4版)中胆红素的参考区间;男性胆红素水平高于女性。不同性别的汉族、维吾尔族健康人群胆红素水平比较,差异均有统计学意义(P<0.05),汉族男、女性总胆红素水平比维吾尔族高,而直接胆红素较低。汉族、维吾尔族18~<30、30~<40、40~<50岁组的总胆红素水平,18~<30、40~<50岁组的直接胆红素水平比较,差异均有统计学意义(P<0.05),两个民族≥50岁组的总胆红素和直接胆红素水平差异无统计学意义(P>0.05)。汉族、维吾尔族胆红素水平的差异随年龄增加而减小。结论乌鲁木齐市健康人群血清胆红素水平高于《全国临床检验操作规程》(第4版)中的参考区间,汉族总胆红素水平高于维吾尔族,直接胆红素水平低于维吾尔族,差异随年龄增加而减小。地区和民族是建立胆红素参考区间的重要因素。
Objective To establish the reference intervals of serum bilrubin among healthy population in Urumqi City,and to explore the difference of bilirubin level between Han and Uygur nationalities.Methods A total of 5478 persons undergoing the healthy physical examination in Urumqi City were screened out by the questionnaire survey and laboratory test.The serum bilirubin levels were retrospectively analyzed and compared.The distribution characteristics of bilirubin in Han and Uygur nationalities were analyzed.Results Serum total bilirubin reference intervals of healthy population in Urumqi City:6.45-29.57μmol/L in male,5.62-25.29μmol/L in female,direct bilirubin:1.50-12.07μmol/L in male,1.05-8.62μmol/L in female;The reference intervals is higher than that in the reference intervals of National Clinical Test Operating Regulations(4th edition).The bilirubin level in male was higher than that in female;the bilirubin level had the statistical difference between different sex in Han and Uygur(P<0.05).The total bilirubin level of Han male and female was higher than that of Uygur,while the direct bilirubin level was lower.The total bilirubin levels in the 18-<30,30-<40 and 40-<50 years old groups had statistical differences between Han and Uygur nationalities and the direct bilirubin levels in the 18-<30 and 40-<50 years old groups had statistical difference between Han and Uygur nationalities(P<0.05);the total bilirubin and direct bilirubin levels in the≥50 years old group had no statistical difference between Han and Uygur nationalities(P>0.05).The difference of bilirubin level between Han and Uygur nationalities was decreased with the age increase.Conclusion The serum bilirubin level of healthy population in Urumqi is higher than that in the reference intervals of National Clinical Test Operating Regulations(4th edition).The total bilirubin level of Han nationality is higher than that of Uygur nationality,while the direct bilirubin is lower,the difference is decreased with the age increase.The region and nationality are the important factors for establishing the reference interval of bilirubin.
作者
王黎
杨成新
李清华
刘洁
张向芝
WANG Li;YANG Chengxin;LI Qinghua;LIU Jie;ZHANG Xiangzhi(Physical Examination Center,Xinjiang Uygur Autonomous Region Occupational Diseases Hospital,Urumqi,Xinjiang 830091,China)
出处
《检验医学与临床》
CAS
2020年第6期744-747,共4页
Laboratory Medicine and Clinic
基金
新疆维吾尔自治区科技厅自然科学基金项目(2017D01A86)。
关键词
胆红素
健康人群
参考区间
bilirubin
healthy population
reference interval
作者简介
王黎,女,主任医师,主要从事职业卫生研究。
