摘要
目的沙利度胺联合来氟米特与甲氨蝶呤治疗类风湿关节炎的效果探究。方法选取患有类风湿关节炎患者80例,将其分为对照组与观察组,每组40例,所有患者均在2017年7月-2018年7月期间于南阳市第二人民医院治疗。两组分别用药,对照组给予来氟米特与甲氨蝶呤治疗,观察组给予沙利度胺联合来氟米特与甲氨蝶呤治疗,并对两组的治疗情况、临床疗效及不良反应情况进行分析对比。结果观察组治疗4周、9周、15周后关节压痛数、ESR及不良反应改善幅度均比对照组明显,观察组总有效率(95.00%)高于对照组总有效率(75.00%),两组对比差异有统计学意义(P<0.05)。结论类风湿关节炎患者采用沙利度胺联合来氟米特与甲氨蝶呤治疗效果更优于采用来氟米特与甲氨蝶呤治疗,加快患者疾病的恢复进程。
Objective To investigate the effect of thalidomide combined with leflunomide and methotrexate in the treatment of rheumatoid arthritis. Methods 80 patients with rheumatoid arthritis treated in the hospital from July, 2017 to July,2018 were divided into control group(n=40) and observation group(n=40). The control group were treated with leflunomide and methotrexate,and the observation group were treated with thalidomide combined with leflunomide and methotrexate. The treatment, clinical efficacy and adverse reactions of the two groups were analyzed and compared. Results In the observation group, the number of joint tenderness, ESR and adverse reactions after 4, 9 and 15 weeks treatment were significantly better than the control group. Compared with the control group, the total effective rate(95.00%) was higher than that of the control group(75.00%), with statistically significant difference(P<0.05). Conclusion Salidomide combined with leflunomide and methotrexate in the treatment of patients with rheumatoid arthritis is better than that of leflunomide and methotrexate, which can increase the recovery process.
作者
马亚琼
MA Ya-qiong(Department of Nephropathy and Rheumatology,Nanyang Second People’s Hospital,Nanyang,Henan,473000,China)
出处
《黑龙江医学》
2020年第2期245-247,共3页
Heilongjiang Medical Journal
