摘要
目的评估血浆髓系相关蛋白(MRP8/14)对心肌梗死后缺血性心肌病患者心肌存活率的预测价值。方法收集2014年6月-2017年4月西安交通大学医学院第一附属医院心血管外科符合纳入标准的心肌梗死后缺血性心肌病患者59例,根据心肌存活率不同分为心肌存活率>10%组(n=27)和心肌存活率≤10%组(n=32)。收集患者临床指标、生化指标,所有患者均采用超声心动图测定心脏结构、左室收缩和舒张功能,SPECT 99Tcm-MIBI和18F-FDG心肌双核素显像评估心肌存活率,ELISA法检测入院24 h内空腹静脉血MRP8/14。采用双变量线性相关分析MRP8/14水平与心脏结构、功能及心肌存活率的关系。结果心肌存活率≤10%组MRP8/14表达水平显著高于心肌存活率>10%组(t=5.702,P<0.01),心肌存活率≤10%组LVEDD显著高于心肌存活率>10%组(t=2.217,P<0.05);MRP8/14表达水平与心肌存活率呈负相关(r=-0.574,P<0.01);MRP8/14预测心肌存活率ROC曲线下面积为0.859,敏感度为78.1%,特异度为77.8%,准确率为78.0%。结论MRP8/14表达水平与心肌存活率存在显著负相关,MRP8/14表达水平是影响心肌存活率的危险因素,其有望成为预测心肌存活率的指标之一。
Objective To evaluate the predictive value of plasma MRP8/14 on myocardial survival in patients with ischemic cardiomyopathy after myocardial infarction.Methods From June 2014 to April 2017,59 patients with ischemic cardiomyopathy after myocardial infarction who met the inclusion criteria in cardiovascular surgery of the First Affiliated Hospital of Xi’an Jiaotong University Medical College were collected.According to the different myocardial survival rates,the patients were divided into two groups:myocardial survival rate>10%(n=27)and myocardial survival rate≤10%(n=32).The clinical and biochemical indexes were collected.Echocardiography was used to determine the structure of the heart,left ventricular systolic and diastolic function.SPECT 99Tcm MIBI and 18 F FDG myocardial binucleate imaging were used to evaluate myocardial viability.MRP8/14 of fasting venous blood was detected by ELISA within 24 hours after admission.The relationship between the level of MRP8/14 and cardiac structure,function and survival rate was analyzed by bivariate linear correlation.Results The expression level of MRP8/14 in the group with myocardial survival rate≤10%was significantly higher than that in the group with myocardial survival rate>10%(t=5.702,P<0.01),and the LVEDD in the group with myocardial survival rate≤10%was significantly higher than that in the group with myocardial survival rate>10%(t=2.217,P<0.05).The expression level of MRP8/14 was negatively correlated with myocardial survival rate(r=-0.574,P<0.01).The area under ROC curve of MRP8/14 was 0.859,the sensitivity was 78.1%,the specificity was 77.8%,and the accuracy was 78.0%.Conclusion The expression level of MRP8/14 has a significant negative correlation with myocardial survival rate.The expression level of MRP8/14 is a risk factor affecting myocardial survival rate,which is expected to become one of the indexes for predicting myocardial survival rate.
作者
王雪
高珩
胡佳文
闫炀
邓超
郑小璞
Wang Xue;Gao Heng;Hu Jiawen;Yan Yang;Deng Chao;Zheng Xiaopu(Department of Cardiovascular Surgery,the First Affiliated Hospital of Xi'an Jiaotong University Medical College,Shaanxi Province,Xi’an 710061,China)
出处
《疑难病杂志》
CAS
2020年第3期217-221,共5页
Chinese Journal of Difficult and Complicated Cases
基金
陕西省重点研发计划项目(2019ZDLSF-01-01)~~
作者简介
通信作者:郑小璞,E-mail:zhengxp001@163.com。
