摘要
目的探讨功能失调性子宫出血的不同治疗时间的疗效。方法收集暨南大学第一临床学院2013年1月至2016年1月门诊和住院的功能失调性子宫出血患者320例,采取规范化人工周期、雌孕激素联合治疗、孕激素后半周期疗法等月经周期控制性治疗,左炔诺孕酮宫内缓释系统等。按照月经周期进行调经、止血治疗,使用药物黄体酮胶囊或地屈孕酮、补佳乐片或雌二醇片,观察治疗1年、2年和3年时的疗效。结果 320例功能失调性子宫出血患者经过治疗,治疗1年时治愈230例,治愈率71.88%,未治愈90例,未治愈者治疗1年后血红蛋白(112.7±21.4)g/L;治疗2年时:治愈62例,治疗第1年和第2年的合计治愈率91.25%,未治愈28例,未治愈者血红蛋白(95.3±19.3)g/L;3年继续治疗者28例:治愈5例,3年的合计治愈率92.81%,未治愈23例,未治愈者血红蛋白(56.1±18.8)g/L。功能失调性子宫出血患者血红蛋白随着治疗时间的延长呈现持续降低趋势。结论功能失调性子宫出血疾病患者经3年的激素治疗后约有7.19%治疗无效并且导致重度贫血,部分患者经长时间治疗仍未能痊愈。病史超过2年且贫血严重的病人不应继续保守治疗,应选择手术治疗方案。
ObjectiveTo study on the effect of different timing of treatment for dysfunctional uterine bleeding.MethodsTotally 320 cases of dysfunctional uterine bleeding treated in our hospital from January 2013 to January 2016 were collected and they were treated by standardized artificial cycle,combined treatment of estrogen and progesterone,second half cycle therapy of progesterone,and the release system of levonorgestrel intrauterine device,etc.Menstruationwas regulated and hemostasis treatment was prerformed according to the menstrual cycle.Progesterone capsules ordidrogesterone,Bujiale tablets or estradiol tablets were used.the 1-year and 3-year effects were observed.Results Among 320 patients with dysfunctional uterine bleeding.receiving treatment,230 were cured in one year,with a cure rateof 71.88%,and 90 patients were uncured,with their hemoglobin being(112.7±21.4)g/L;62 cases were cured at the end oftwo-year treatment,the total one-year and two-year cure rate being 91.25%,and 28 were uncured,with their hemoglobinbeing(95.3±19.3)g/L;28 patients received continuous treatment for 3 years,of whom 5 were cures and the 3-year curerate was 92.81%;23 cases were uncured and their hemoglobin was(56.1 ± 18.8)g/L.The hemoglobin of patients withdysfunctional uterine bleeding was continuously decreasing with the prolongation treatment.ConclusionAbout 7.19%of patients with dysfunctional uterine bleeding are irresponsive to 3-year hormone treatment,and the treatment results insevere anemia. Some patients are not cured after a long time of treatment.refractory dysfunctional uterine bleeding inpatients with a history of more than two years and no response to treatment should be considered,conservative treatmentshould no longer be accepted.
作者
郭玉峰
罗新
张颖
GUO Yu-feng;LUO Xin;ZHANG Ying(Department of Obstetrics and Gynecology,First Clinical College^Jinan University,Guangzhou 510632,China)
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
2020年第2期182-184,共3页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
功能失调性子宫出血
月经
贫血
dysfunctional uterine bleeding
menstruation
anemia
作者简介
通讯作者:张颖,电子信箱:zhangying5413@126.com。
