摘要
胎儿及新生儿免疫溶血性疾病是由母体IgG型同种免疫性红细胞抗体进入胎儿体内,作用于表达抗体对应抗原的胎儿红细胞,以胎儿及新生儿溶血为主要病理过程,以贫血和新生儿黄疸为主要临床表现的围产期常见疾病。本文综述了国内外近年来在胎儿及新生儿免疫溶血性疾病的病理生理、红细胞同种免疫性抗体与胎儿及新生儿免疫溶血性疾病的临床相关性、妊娠同种免疫的实验室检测,以及胎儿及新生儿免疫溶血性疾病高危病例的临床评估、治疗和预防方面的研究进展。
Hemolytic disease in fetuses and newborns(HDFN)is a common perinatal condition caused by the destruction of erythrocytes of neonates or fetuses by maternal IgG antibodies.Fetal or neonatal hemolysis is HDFN's primary pathological process resulting in anemia and neonatal jaundice.This review summarized recent progress in the pathophysiology of HDFN,the clinical correlation between anti-erythrocyte alloantibodies and HDFN,laboratory tests for alloimmunization in pregnancy,clinical evaluation of high-risk cases of HDFN,and treatment and prevention of HDFN at home and abroad.
作者
吴远军
隗伏冰
杨勇
Wu Yuanjun;Yu Fubing;Yang Yong(Department of Blood Transfusion,Dongguan Maternal and Child Health Care Hospital,Dongguan 523120,China;Department of Obstetrics,Dongguan Maternal and Child Health Care Hospital,Dongguan 523120,China;Department of Neonatology,Dongguan Maternal and Child Health Care Hospital,Dongguan 523120,China)
出处
《中华围产医学杂志》
CAS
CSCD
北大核心
2020年第1期44-51,共8页
Chinese Journal of Perinatal Medicine
基金
2019年东莞市社会科技发展(重点)项目(201950715007214)。
作者简介
通信作者:隗伏冰,Email:yufbing@l26.com,电话:0769-23329886。
