摘要
由于抗菌药物的不合理使用,造成细菌耐药率逐年升高。抗菌药物的药物代谢动力学/药物效应动力学(PK/PD)研究可充分考虑病原体、宿主和药物三者的相互关系,反映抗菌药物杀菌效应及不良反应与血药浓度变化之间的关系,对抗菌药物的开发及使用等具有重要价值。从PK/PD模型、相关理论及其在临床应用等方面进行综述,旨在为临床合理使用抗菌药物,减少耐药菌的产生提供参考。
Due to the irrational use of antimicrobial agents,bacterial resistance has been increasing year by year.PK/PD study fully considers the relationship among pathogens,hosts and drugs,which reflects the relationship between bactericidal effects and adverse reactions of antibiotics and the change of blood concentration,which is of much value to the development and application of antibiotics.In this paper,the basic theory of PK/PD,related models and clinical applications are reviewed,with an aim to provide a basis for the rational use of antimicrobial agents and the reduction of drug-resistant bacteria.
作者
沈爱宗
张圣雨
陈泳伍
晨迪
陈飞虎
黄晓晖
邵蓉
SHEN Aizong;ZHANG Shengyu;CHEN Yongwu;CHEN Di;CHEN Feihu;HUANG Xiaohui;SHAO Rong(School of International Pharmaceutical Business,China Pharmaceutical University,Nanjing 211198,China;Department of Pharmacy,the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital),Hefei 230001,China;College of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China;College of Pharmacy,Anhui Medical University,Hefei 230032,China)
出处
《药学进展》
CAS
2019年第11期880-880,I0003-I0006,共5页
Progress in Pharmaceutical Sciences
作者简介
通讯作者:邵蓉博士、教授、博士生导师,中国药科大学国家药物政策与医药产业经济研究中心执行副主任。工业信息化部安全生产专家组成员,国家中药品种保护评审委员会审评专家,国家药品监督管理局仿制药质量和疗效一致性评价专家委员会专家,中国药学会和中国药品监督管理研究会等多家学(协)会理事、常务理事、专委会主委和副主委。主持国家社科基金项目重大和面上项目、国家各部委重点研究和企业委托项目百余项。《亚洲社会药学》副主编、《中国药房》《中国新药杂志》《中国卫生政策研究》等十余个杂志编委。Tel:025-86185287,E-mail:shaorong118@163.com。
