摘要
目的:探讨磁共振灌注成像(magnetic resonance perfusion weighted imaging,MR-PWI)对鼻咽癌放疗靶区勾画和剂量学的影响。方法:收集20例初治的鼻咽癌患者,分别行CT、MR、MR-PWI扫描定位,然后分别勾画靶区得到原发灶大体肿瘤靶区(gross tumor volume of primary tumor,GTV-t)和淋巴结转移灶靶区(gross tumor volume of metastatic lymphadenopathy,GTV-n)的绝对体积及相关危及器官的平均剂量和最大剂量,进行对比分析。结果:CT组勾画的GTV-t体积较MR组、MR-PWI组大,差异有统计学意义(P<0.05),MR组较CT组勾画的GTV-n体积小,两组对比差异有统计学意义(P<0.05)。脑干所受最大剂量在MR-PWI组和CT组比较差异有统计学意义(P<0.05),但平均剂量在不同组间的差异均无统计学意义(P>0.05)。结论:MR勾画靶区在确定靶区边界上较CT更精确,MR-PWI作为辅助显像方法,可作为靶区勾画的参考。
Objective:To investigate and discuss the influence of magnetic resonance perfusion weighted imaging(MR-PWI)on target volume delineation and dosimetry in radiotherapy for nasopharyngeal carcinoma(NPC).Methods:We collected 20 NPC patients.Images of computed tomography(CT),magnetic resonance(MR),and MR-PWI were taken.Then we obtained the absolute gross tumor volume[primary tumor(GTV-t),metastatic lymphadenopathy(GTV-n)],and mean dose and maximum dose of organs at risk for statistical analysis.Results:Volume of GTV-t in the CT group was larger than those in MR and MR-PWI group.The difference was statistically significant(P<0.05).Volume of GTV-n in the MR group was smaller than that in the CT group,and the difference between the two groups was statistically significant(P<0.05).Maximum brainstem dose was significantly different between the MR-PWI group and the CT group(P<0.05).Mean brainstem dose was not significantly different among different groups(P>0.05).Conclusion:MR is more accurate than CT for target volume delineation in determining boundary of target area.MR-PWI as an auxiliary imaging method can be used as a reference for target delineation.
作者
张白雪
谭叶
陆静钰
王效军
陆海军
Zhang Baixue;Tan Ye;Lu Jingyu;Wang Xiaojun;Lu Haijun(Department of Oncology,People’s Hospital of West Shore New District,Qingdao 266400,Shandong,China;Department of Radiation Oncology,The Affiliated Hospital of Qingdao University,Qingdao 266000,Shandong,China;Department of Otorhinolaryngology,The Affiliated Hospital of Qingdao University,Qingdao 266000,Shandong,China;Clinical College,Binzhou Medical University,Yantai 264000,Shandong,China)
出处
《肿瘤预防与治疗》
2020年第1期15-19,共5页
Journal of Cancer Control And Treatment
基金
国家卫生计生委医院管理所项目(编号:WJWYGS-201818)~~
关键词
鼻咽癌
磁共振灌注成像
放射治疗
Nasopharyngeal carcinoma
Perfusion weighted imaging
Radiotherapy
作者简介
共同第一作者:张白雪;共同第一作者:谭叶;通讯作者:陆海军,E-mail:lhj82920608@163.com。
