摘要
心肌梗死是心血管疾病死亡的主要原因。其发病机制尚未完全阐明,研究发现RhoA/ROCK信号通路在内皮功能障碍、炎症反应、氧化应激、内质网应激和细胞凋亡等过程中起关键作用,与心肌梗死的发生和发展紧密相关。ROCK抑制剂也为心肌梗死的治疗提供了一条新思路。现就近年RhoA/ROCK信号通路在心肌梗死中的发病机制做一综述。
Myocardial infarction is the main cause of death from cardiovascular disease.Its pathogenesis has not been fully elucidated.The research found that RhoA/ROCK signaling pathway is related to the occurrence and development of myocardial infarction in endothelial dysfunction,inflammatory response,oxidative stress,endoplasmic reticulum stress and cell apoptosis.Futhermore ROCK inhibitor display a new approach for the treatment of myocardial infarction.This article reviews the pathogenesis of RhoA/ROCK signaling pathway in myocardial infarction.
作者
薛万腾
吕志慧
高向向
黄帅
王营忠
XUE Wanteng;L Zhihui;GAO Xiangxiang;HUANG Shuai;WANG Yingzhong(The Affiliated Hospital of Yan’an University,Yan’an 716000,Shaanxi,China)
出处
《心血管病学进展》
CAS
2019年第9期1282-1285,共4页
Advances in Cardiovascular Diseases
作者简介
通讯作者:王营忠,E-mail:1187448977@qq.com。
