摘要
随着研究的不断深入,炎症因子与急性心肌梗死(AMI)的相关性越来越受到关注。白细胞介素-6(IL-6)、白细胞介素-17(IL-17)是目前研究较多的炎症因子,其可通过多种途径参与动脉粥样硬化发生及斑块形成,导致斑块的不稳定,促使AMI患者病情进展,从而引起心肌纤维化和左心室重塑等病理改变。大量研究表明,AMI患者检测IL-6、IL-17可进一步评估病情严重程度及预后,可能有助于为临床干预AMI找到新靶点。
With the deepening of research,the correlation between inflammatory factors and acute myocardial infarction(AMI)has been paid more and more attention.Inflammatory factors including interleukin-6(IL-6)and interleukin-17(IL-17)are the most studied factors currently,which can participate in atherosclerosis and plaque formation through a variety of ways,and lead to plaque.The instability of plaque promotes the progression of AMI patients,leading to pathological changes such as myocardial fibrosis and left ventricular remodeling.A large number of studies have shown that the detection of IL-6 and IL-17 in AMI patients can further assess the severity and prognosis of the disease,and may find new targets of AMI by clinical intervention.
作者
周学红
张晶
ZHOU Xuehong;ZHANG Jing(Affiliated Luhe Hospital of Medical College of Yangzhou University,Nanjing,Jiangsu,211500;Subei People′s Hospital Affiliated to Yangzhou University,Yangzhou,Jiangsu,225000)
出处
《实用临床医药杂志》
CAS
2020年第1期128-132,共5页
Journal of Clinical Medicine in Practice
作者简介
通信作者:张晶,E-mail:zhangjingyjs@163.com。
