摘要
目的探讨阿奇霉素联合特布他林治疗小儿支气管肺炎的效果及对患儿肺功能的影响。方法选取我院2017年9月至2019年3月收治的126例支气管肺炎患儿作为研究对象,按电脑随机数字表法将其分为对照组(63例,阿奇霉素)和试验组(63例,阿奇霉素+特布他林)。比较两组的炎症因子、心肌酶谱水平及肺功能指标。结果治疗后,两组的粒细胞集落刺激因子(G-CSF)、可溶性白细胞介素-2受体(SIL-2R)水平均降低,且试验组明显低于对照组(P<0.05)。治疗后,两组的肌酸激酶(CK)、α-羟丁酸脱氢酶(α-HBDH)水平均降低,且试验组明显低于对照组(P<0.05)。治疗后,两组的呼气流量峰值(PEF)、1 s用力呼气容积(FEV1)、用力肺活量(FVC)均升高,且试验组明显高于对照组(P<0.05)。结论阿奇霉素联合特布他林治疗小儿支气管肺炎可降低炎症因子、心肌酶谱水平,有效缓解病情,进而改善患儿肺功能。
Objective To explore the effect of azithromycin combined with terbutaline in the treatment of pediatric bronchial pneumonia and its influences on pulmonary function of children. Methods A total of 126 children with bronchial pneumonia treated in our hospital from September 2017 to March 2019 were selected as the study objects and divided into control group(63 cases, azithromycin) and experimental group(63 cases, azithromycin +terbutaline) according to the computer random number table method. The levels of inflammatory factors, myocardial enzymes and pulmonary function index were compared between the two groups. Results After treatment, the levels of granulocyte colony stimulating factor(G-CSF) and soluble interleukin-2 receptor(SIL-2R) in the two groups decreased, and those in the experimental group were significantly lower than the control group(P <0.05). After treatment, the levels of creatine kinase(CK) and α-hydroxybutyrate dehydrogenase(α-HBDH) in the two groups decreased, and those in the experimental group were significantly lower than the control group(P<0.05). After treatment, peak expiratory flow(PEF), forced expiratory volume in one second(FEV1) and forced vital capacity(FVC) in the two groups increased, and those in the experimental group were significantly higher than the control group(P<0.05). Conclusion Azithromycin combined with terbutaline in the treatment of pediatric bronchial pneumonia can effectively reduce the levels of inflammatory factors and myocardial enzymes, as well as effectively alleviate the disease, thus improving the pulmonary function of the children.
作者
杜赢
DU Ying(Xi'an Union Hospital,Xi'an 710100,China)
出处
《临床医学研究与实践》
2020年第2期115-117,共3页
Clinical Research and Practice
关键词
阿奇霉素
特布他林
小儿支气管肺炎
肺功能
azithromycin
terbutaline
pediatric bronchial pneumonia
pulmonary function
作者简介
杜赢(1971-),男,汉族,陕西咸阳人,副主任医师,学士。研究方向:儿科呼吸与消化。
