摘要
目的分析呼吸道感染病原体在郑州地区住院患者中的流行特征。方法选取2018年5月至2019年4月河南省中医院1708例呼吸道感染住院患者,采用间接免疫荧光法检测9项呼吸道感染病原体[嗜肺军团菌血清1型(LP1)、肺炎支原体(MP)、Q热立克次体(COX)、肺炎衣原体(CPn)、腺病毒(ADV)、呼吸道合胞病毒(RSV)、甲型流感病毒(INFA)、乙型流感病毒(INFB)和副流感病毒(PIVs)]IgM抗体,并对结果进行统计分析。结果共检出呼吸道感染病原体IgM抗体阳性847例,总检出率为49.6%,其中单一感染432例(25.3%),混合感染415例(24.3%),MP阳性检出率最高(36.7%),其次为INFB(21.9%)和PIVs(15.7%)。女性阳性检出率高于男性,差异有统计学意义(P<0.001),INFB、ADV、RSV、PIVs、MP阳性检出率年龄段分布比较,差异有统计学意义(均P<0.05)。阳性标本检出最多的月份为12、1、11月,检出率分别为58.1%、56.7%、48.1%。MP、INFB、PIVs和RSV各月检出率比较,差异有统计学意义(均P<0.05);患者性别、年龄及月份是呼吸道病原体感染的独立危险因素(均P<0.05),女性感染风险是男性的1.5倍,随年龄增加感染风险有所降低。结论9种呼吸道感染病原体的流行特征差异较大;女性阳性检出率高于男性;1~6岁年龄段阳性检出率最高,并集中分布在冬季;MP是引起呼吸道感染的主要病原体;女性、低龄、寒冷季节(12、1月)是呼吸道病原体感染的独立危险因素。
Objective To analyze the epidemic characteristics of pathogens of respiratory tract infection among inpatients in Zhengzhou.Methods A total of 1708 hospitalized patients with respiratory tract infection in Henan Province Hospital of Traditional Chinese Medicine from May 2018 to April 2019 were selected.Indirect immunofluorescence assay was used to detect IgM antibodies of 9 respiratory pathogens[Legionella pneumophila 1(LP1),mycoplasma pneumonia(MP),coxiella burnetii(COX),chlamydia pneumonia(CPn),adenovirus(ADV),respiratory syncytial virus(RSV),influenza virus A(INFA),influenza virus B(INFB)and parainfluenza virus(PIVs)],and the results were statistically analyzed.Results A total of 847 cases with positive IgM antibodies against pathogens of respiratory tract infection were detected,and the total detection rate was 49.6%.Among them,432 cases(25.3%)were single infection,and 415 cases(24.3%)were mixed infection.The positive rate of MP was the highest(36.7%),followed by INFB(21.9%)and PIVs(15.7%).The positive rate of females was higher than that of males,and the difference was statistically significant(P<0.001).The positive rates of INFB,ADV,RSV,PIVs and MP in different age groups were significantly different(all P<0.05).The months with the highest number of positive specimens detected were December,January and November,and the detection rates were 58.1%,56.7%and 48.1%,respectively.The detection rates of MP,INFB,PIVs and RSV were compared in each month,and the differences were statistically significant(all P<0.05).Gender,age and month were independent risk factors for respiratory pathogen infection(all P<0.05).Women were 1.5 times more likely to be infected than men.The risk of infection decreased with age.Conclusion The epidemic characteristics of 9 pathogens of respiratory tract infection were different.Women have a higher positive detection rate than men.The positive detection rate was highest in the age group of 1 to 6 years old,which was concentrated in winter.MP is the main pathogen that causes respiratory tract infection.Female,low age and cold season(December,January)are independent risk factors for respiratory pathogen infection.
作者
付宗强
刘豆豆
张汇征
牛小斌
李永伟
FU Zong-qiang;LIU Dou-dou;ZHANG Hui-zheng;NIU Xiao-bin;LI Yong-wei(Clinical laboratory,Henan Province Hospital of Traditional Chinese Medicine/the Second Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450002,China;Medical College of Laboratory Medicine,Wenzhou Medical University,Wenzhou 325000,China;Central Laboratory,Chongqing Public Health Medical Center,Chongqing 400036,China)
出处
《河南医学研究》
CAS
2020年第1期1-5,共5页
Henan Medical Research
关键词
呼吸道感染
病原体
郑州
住院患者
间接免疫荧光
respiratory infection
pathogen
Zhengzhou
inpatients
indirect immunofluorescence
作者简介
通信作者:李永伟,E-mail:hnszyy@qq.com。
