摘要
细胞自噬是古老的先天性免疫防御。免疫受体SQSTM1样受体(SLRs)、Toll样受体(TLRs)、RIG-1样受体(RLRs)、Nod样受体(NLRs)、双链RNA依赖的蛋白激酶(PKR)以及病原体受体CD46都能识别病原体,进而诱导细胞自噬的发生来抵抗病原体的入侵。细胞自噬还能影响先天性免疫信号通路进而调控I型干扰素的产生,先天性免疫分子反过来也能加强细胞自噬的作用来清除病原体,这充分体现了细胞自噬的先天性免疫防御作用。此外,死亡相关蛋白激酶(DAPK)、c-Jun氨基末端激酶1(JNK1)、高迁移率族蛋白B1(HMGB1)以及自噬相关蛋白Becline1的K63多聚泛素化对细胞自噬同样存在调控作用。虽然运动通过AMP依赖的蛋白激酶(AMPK)/哺乳动物雷帕霉素靶蛋白(mTOR)等途径调控细胞自噬已被研究证实,但运动是否通过上述免疫受体及相关分子来调控细胞自噬有待考证。并且,运动诱导的细胞自噬在先天性免疫反应过程中的作用目前仍不清楚,因此,研究主要从细胞自噬的角度探讨运动对先天性免疫的调控作用,以期为运动对先天性免疫的影响研究提供新的思路。
Autophagy is a kind of fundamental innate immunity defense.The immune receptors,including sequestasome-like receptors(SLRs),toll-like receptors(TLRs),RIG-I-like receptors(RLRs),nod-like receptors(NLRs),dsRNA-dependent protein kinase(PKR),and pathogen receptor CD46,can identify pathogens and then induce autophagy to resist the invasion of pathogens.The autophagy can also affect the innate immune signaling pathway to further regulate the production of type I interferon,while the innate immune molecules in turn can enhance the role of autophagy to remove pathogens,all of these mechanisms reflect the innate immune defense role of autophagy.In addition,the K63 polyubiquitination of death-associated protein kinase(DAPK),c-jun Nterminal kinase 1(JNK1),high mobility group box-1 protein(HMGB1)and autophagy related protein Becline1 also have regulatory effects on autophagy.Studies have confirmed that exercise regulates autophagy through AMP-activated protein kinase(AMPK)/mammalian target of rapamycin(mTOR)pathways,however,whether exercise regulates autophagy through the above immune receptors and related molecules remains to be confirmed,and the role of exercise-induced autophagy in the innate immune response process is still unclear.This study mainly discussed the regulation effect of exercise on innate immunity from the perspective of autophagy,so as to provide new research ideas in investigating the effects of exercise on innate immunity.
作者
戈哲
丁树哲
GE Zhe;DING Shuzhe(Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education,East China Normal University,Shanghai 200241,China;College of Physical Education&Health,East China Normal University,Shanghai 200241,China)
出处
《体育科学》
CSSCI
北大核心
2019年第11期67-74,共8页
China Sport Science
基金
国家自然科学基金资助项目(31671241)
作者简介
第一作者:戈哲(1992-),男,在读博士研究生,主要研究方向为运动对健康作用的细胞分子机制,E-mail:gezhe9001@163.com;通信作者:丁树哲(1963-),男,教授,博士,博士研究生导师,主要研究方向为运动适应与线粒体调控,E-mail:szding@tyxx.ecnu.edu.cn。
