摘要
目的观察早期持续气道正压通气(CPAP)联合肺表面活性物质(PS)对新生儿呼吸窘迫综合征(NRDS)的治疗效果,并分析其安全性。方法选取2017年9月至2019年2月宿迁巿泗洪县人民医院收治的60例NRDS患儿,分为对照组和研究组,各30例。对照组患儿通过气管插管注入PS,研究组在此基础上联合CPAP。比较两组血气指标、治疗有效率以及并发症发生情况。结果两组患儿的动脉pH、血氧分压(PaO2)以及氧合指数(PaO2/FiO2)较治疗前均有显著提高,PaCO2显著下降,且研究组提高或降低的程度优于对照组(P<0.05);研究组的治疗总有效率显著高于对照组(P<0.05);研究组患儿的住院时间显著短于对照组,研究组患儿的总不良反应发生率较显著低于对照组(P<0.05)。结论对NRDS的患儿采用CPAP与PS联合的方式进行治疗可有效恢复患儿肺功能,有效率高、并发症少。
Objective To observe the therapeutic effect of early continuous positive airway pressure(CPAP)combined with pulmonary surfactants(PS)on neonatal respiratory distress syndrome(NRDS)and analyze its safety.Methods From September 2017 to February 2019,60 NRDS patients admitted to suqian people's hospital were selected and divided into control group and study group,30 cases each.The control group was injected with PS,while on the basis of the control group the study group were combined with CPAP.The blood gas index,the effective rate of treatment and the occurrence of complications between the two groups were compared.Results The arterial pH,PaO2 and PaO2/FiO2 of the two groups of children were significantly improved compared with the pre-treatment,while PaCO2 was significantly decreased,and the degree of increase or decrease of the study group was better than that of the control group(P<0.05).The total effective rate of treatment in the study group was significantly higher than that in the control group(P<0.05).The hospital stay in the study group was significantly shorter than that in the control group,and the incidence of total adverse reactions in the study group was significantly lower than that in the control group(P<0.05).Conclusion The combined treatment of CPAP and PS in children with NRDS can effectively restore pulmonary function,the effective rate is high and the complications are few.
作者
张靖
ZHANG Jing(Sihong County People's Hospital,Suqian City,Jiangsu Province,Suqian,Jiangsu 223900,China)
出处
《大医生》
2019年第15期71-72,共2页
Doctor
关键词
肺表面活性物质
持续正压通气
新生儿呼吸窘迫综合征
pulmonary surfactants
continuous positive pressure ventilation
neonatal respiratory distress syndrome
作者简介
张靖,本科,副主任医师,研究方向:儿内科。
