摘要
目的探讨文拉法辛与草酸艾司西酞普兰治疗抑郁症的临床疗效.方法68例确诊为抑郁症患者,随机分为文拉法辛组和草酸艾司西酞普兰组,每组34例.文拉法辛组采用文拉法辛进行治疗,草酸艾司西酞普兰组采用草酸艾司西酞普兰进行治疗.比较两组患者不同时间点(治疗前及治疗1、4、6、8周)汉密尔顿抑郁量表(HAMD)评分、临床疗效及不良反应发生情况.结果两组患者治疗前及治疗1、4、6、8周的汉密尔顿抑郁量表评分比较差异均无统计学意义(P>0.05);但两组患者治疗1、4、6、8周的汉密尔顿抑郁量表评分均低于治疗前,且呈逐渐降低趋势,差异具有统计学意义(P<0.05).治疗8周后,文拉法辛组显效率为73.53%,总有效率为94.12%;草酸艾司西酞普兰组显效率为70.59%,总有效率为91.18%;两组患者的显效率和总有效率比较差异均无统计学意义(P>0.05).两组患者的口干、头晕头痛、疲劳、睡眠障碍、便秘、多汗、厌食、胃肠道反应的发生率比较差异均无统计学意义(P>0.05).所有药物不良反应均发生在用药后2周,且不良反应均相对较轻,对症处理后均改善.结论文拉法辛和草酸艾司西酞普兰对抑郁症患者进行治疗同样安全有效.
Objective To discuss the clinical efficacy of venlafaxine and escitalopram oxalate in the treatment of depression.Methods A total of 68 depression patients were randomly divided into venlafaxine group and escitalopram oxalate group,with 34 cases in each group.Venlafaxine group was treated by venlafaxine,and escitalopram oxalate group was treated by escitalopram oxalate.The Hamilton depression scale(HAMD)score at different time points(before treatment and after 1,4,6,8 weeks of treatment),clinical efficacy and occurrence of adverse reaction was compared between the two groups.Results There was no statistically significant difference in Hamilton depression scale score before treatment and after 1,4,6,8 weeks of treatment between the two groups(P>0.05).The Hamilton depression scale score after 1,4,6,8 weeks of treatment in the two groups was lower than those before treatment,and gradually decreased.Their difference was statistically significant(P<0.05).After 8 weeks of treatment,the excellent rate and total effective rate was 73.53% and 94.12% respectively in venlafaxine group,which was 70.59% and 91.18% respectively in escitalopram oxalate group.There was no statistically significant difference in excellent rate and total effective rate between the two groups(P>0.05).There was no statistically significant difference in incidence of dry mouth,dizziness and headache,fatigue,sleep disorder,constipation,hyperhidrosis,anorexia,gastrointestinal reaction between the two groups(P>0.05).All adverse drug reactions occurred 2 weeks after administration,and the adverse reactions were relatively mild,and improved after symptomatic treatment.Conclusion Venlafaxine and escitalopram oxalate are equally safe and effective in treating patients with depression.
作者
姚烨
YAO Ye(Dalian Seventh People’s Hospital,Dalian 116031,China)
出处
《中国现代药物应用》
2019年第24期17-19,共3页
Chinese Journal of Modern Drug Application
