摘要
目的分析芳香化酶抑制剂来曲唑应用于青春早中期男童对其特性及线性生长的影响。方法选取本院2016年1月至2018年1月收治的预测成年身高受损青春早中期男童30例为研究组,均给予来曲唑治疗,每天服用1.5 mg/m2,另选取30例同期在本院体检的青春早中期健康男童为对照组,不给予药物干预治疗,比较两组治疗前以及治疗1年后的生长特性和线性生长改变情况。结果干预前,两组骨龄、年龄、BMI、睾丸容积以及身高标准差分值比较,差异均无统计学意义(均P>0.05);干预后,研究组骨龄抑制(△BA/△CA)明显,差异有统计学意义(P<0.05);睾丸容积为(7.3±2.8)ml,显著高于对照组(4.5±1.2)ml,差异有统计学意义(P<0.05);研究组预测成年身高、胰岛素生长因子1(IGF-1)与对照组比较,差异均有统计学意义(均P<0.05)。结论在青春早中期男童中应用来曲唑,可有效抑制骨龄,改善男童最终身高,实现青春期男童的线性生长。
Objective To analyze the effect of aromatase inhibitor letrozole on the characteristics and linear growth of boys in early and middle youth period.Methods Thirty children in early-middle youth period who were to be impaired in adult height and treated in our hospital from January,2016 to January,2018 were enrolled as a study group.They were treated with letrozole,1.5 mg/m2 per day.And 30 healthy boys in the early and middle youth stage taking physical examination during the same time period were selected as a control group,and took no drug intervention.The growth characteristics and linear growth changes of the two groups before treatment and after 1 year’s treatment were compared.Results There were no statistical differences in bone age,age,BMI,testicular volume,and height between the study group and the control group before the intervention(all P>0.05).After the intervention,the bone age of the study group was significantly inhibited(P<0.05);the testicular volume of the study group was(7.3±2.8)ml,which was significantly higher than that of the control group[(4.5±1.2)ml,P<0.05];The study group’s predicted adult height and insulin growth factor 1(IGF-1)were significantly different from the control group’s(both P<0.05).Conclusion The used of letrozole in boys in early and middle youth stage can effectively inhibit bone age,improve their final height,and achieve their linear growth.
作者
彭子俊
Peng Zijun(Department of Pediatrics,Foshan First People's Hospital,Foshan 528000,China)
出处
《国际医药卫生导报》
2019年第23期3855-3856,3877,共3页
International Medicine and Health Guidance News
基金
佛山市卫生和计生局项目(20190001)。
