摘要
目的观察乌金祛湿酒对类风湿关节炎患者的临床效果。方法选取2014年3月~2015年3月就诊于北京老年医院门诊符合纳入标准的87例类风湿关节炎患者,按照随机数字表法将其分为观察组(44例)和对照组(43例)。观察组服用乌金祛湿酒,每日早、晚各1次,每次口服10 mL;对照组服用甲氨喋呤,每周1次,每次10 mg。疗程均为8周。观察并记录治疗前后患者日常疼痛视觉模拟评分(VAS评分)、关节疼痛数、关节肿胀数、晨僵持续时间等;治疗前后红细胞沉降率(ESR)、C反应蛋白(CRP)及类风湿因子(RF)和治疗期间非甾体抗炎药的服用情况。结果治疗后观察组达标率高于对照组,差异有统计学意义(P <0.05);与治疗前比较,治疗后两组VAS评分、关节疼痛数、关节肿胀数、晨僵持续时间以及ESR、CRP、RF等实验室指标均降低(P <0.05),且观察组低于对照组(P <0.05);治疗期间,观察组非甾体抗炎药的使用率、不良反应发生率低于对照组,差异有统计学意义(P <0.05)。结论乌金祛湿酒可有效治疗类风湿关节炎,在缓解临床症状及体征方面较甲氨喋呤更具优势,且不良反应较甲氨喋呤少。
Objective To observe the clinical effect of Wujin Qushi Decoction on patients with rheumatoid arthritis(RA). Methods A total of 87 patients with RA admitted to Beijing Geriatric Hospital from March 2014 to March 2015 met the inclusion criteria were selected. They were divided into the observation group(44 cases) and the control group(43 cases) randomly according to the random number table method. The observation group was given Wujin Qushi Decoction once a day in the morning and once in the evening, each time taking 10 m L orally. And the control group was given Methotrexate 10 mg once a week. Both groups had treatment for 8 weeks. During the treatment, VAS score, number of joint pain, swollen joint count, morning stiffness duration, adverse reactions, erythrocyte sedimentation rate(ESR), C-reactive protein(CRP), rheumatoid factor(RF) and the use of non-steroidal anti-inflammatory drug(NSAIDs)were measured. Results After the treatment, the control rate of the observation group was higher than that of the control group, the difference was statistically significant(all P < 0.05). Compared with before treatment, VAS score, number of joint pain, swollen joint count, morning stiffness duration, ESR, CRP, RF and other laboratory indicators in the two groups were all reduced after treatment(P < 0.05), and the observation group was lower than control group(P < 0.05).The use rate of non-steroidal anti-inflammatory drugs and incidence of adverse reactions in the observation group were lower than those in the control group, and the differences were statistically significant(P < 0.05). Conclusion Wujin Qushi Decoction is effective in the treatment of rheumatoid arthritis, and has more advantages than Methotrexate in relieving clinical symptoms and signs, and the adverse reactions are less than Methotrexate.
作者
李娟红
刘宏福
李桂英
LI Juanhong;LIU Hongfu;LI Guiying(Pain Department,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Nuclear Medicine Department,Beijing Geriatric Hospital,Beijing 100095,China)
出处
《中国医药导报》
CAS
2019年第31期131-134,共4页
China Medical Herald
关键词
类风湿关节炎
乌金祛湿酒
甲氨蝶呤
随机对照试验
Rheumatoid arthritis
Wujin Qushi Decoction
Methotrexate
Random-controlled trial
作者简介
李娟红(1970-),女,硕士,主任医师,研究方向:顽固性神经痛和骨关节疼痛的中西医诊治与精准微创术治疗。
