摘要
目的了解青岛地区围产期妇女B族链球菌(Group B streptococcus,GBS)的定植率、抗菌药物敏感性及血清型分布。方法收集2017年12月-2018年12月在我院门诊就诊的妊娠35-37周孕妇的阴道和直肠拭子,进行细菌培养和鉴定,并统计其定植率。应用凝集法进行血清型分型。采用VITEC 2Compact全自动细菌鉴定及药敏系统做药敏分析,对红霉素耐药和克林霉素敏感或中介的菌株进行D试验。结果筛查1265例孕晚期妇女标本,检出GBS 54株,定植率为4.3%。最常见的血清型为Ⅲ型(44.4%)和Ⅰb型(31.5%)。所有菌株对青霉素、氨苄青霉素、利奈唑胺、万古霉素均敏感,对红霉素、克林霉素和左氧氟沙星的耐药率分别为66.7%、75.9%和74.1%。D试验阳性率为87.5%。结论青岛孕产妇GBS的定植率在全国处于偏低水平;Ⅲ型和Ⅰb型为GBS的主要流行血清型;孕晚期GBS感染的妇女应及时进行抗生素预防治疗,β内酰胺类抗生素仍可作为其首选药物。
Objective To investigate the colonization prevalence,antimicrobial susceptibility and serotype distribution of group B streptococcus(GBS)in perinatal women in Qingdao.Methods Vaginal-rectal swabs were collected from pregnant women at 35 to 37 weeks’gestation from Dec 2017 to Dec 2018 in our hospital.After culturing and identification,the colonization rate was calculated and serotypes were identified by the agglutination method.Antimicrobial susceptibility testing was carried out by VITEC 2 Compact automatic bacterial identification and antimicrobial sensitivity analysis system.The D test was needed for the isolates with erythromycin resistance and clindamycin-sensitive or intermediate.Results 54 isolates of GBS were detected in 1265 specimens from the late pregnant women,and the colonization rate with GBS was 4.3%.SerotypesⅢ(44.4%)andⅠb(31.5%)were the most frequent among 54 GBS isolates evaluated.All isolates were sensitive to penicillin,ampicillin,linazolamine and vancomycin,whereas the resistance of isolates to erythromycin,clindamycin and levofloxacin was 66.7%,75.9%and 74.1%,respectively.The positive rate of D test was 87.5%.Conclusion The prevalence of GBS in parturients in Qingdao is at a low level in the range of China.SerotypesⅢandⅠb are predominant serotype.Women infected with GBS in the third trimester of pregnancy should be treated with antibiotics in time,andβ-lactam antibiotics continue to be the first choice for treatment and prevention against GBS infection.
作者
宋海燕
郑旭
由晓颜
刘丰海
SONG Hai-yan;ZHENG Xu;YOU Xiao-yan(Clinical Laboratory Diagnostics,Medical Department of Qingdao University,Qingdao 266021,China;不详)
出处
《中国实验诊断学》
2019年第11期1937-1939,共3页
Chinese Journal of Laboratory Diagnosis
关键词
B族链球菌
定植率
耐药性
血清分型
孕晚期
Group B streptococcus
Colonization prevalence
Antimicrobial resistance
Serotypes
Late pregnancy
作者简介
通讯作者:刘丰海。
