摘要
目的比较麻黄碱与去氧肾上腺素预防剖宫产术中出现仰卧位低血压综合征的临床效果。方法将2016年1月-2018年6月医院收治的剖宫产孕妇150例随机分为观察组及对照组各75例。2组均实施椎管内麻醉。对照组首次静脉泵入麻黄碱注射液5 mg,后根据血压情况每次5 mg静脉追加;观察组产妇静脉泵入去氧肾上腺素5μg/kg,后根据血压情况每次5μg/kg静脉追加。比较2组剖宫产时间、术中补液量、MAP、HR、新生儿Apgar评分及不良反应发生情况。结果 2组剖宫产手术时间及术中补液量比较差异均无统计学意义(P>0.05);观察组MAP、新生儿Apgar评分均高于对照组,HR低于对照组,差异均有统计学意义(P<0.05)。观察组不良反应发生率为12.00%低于对照组的30.67%,差异均有统计学意义(χ^2=5.76,P<0.05)。结论在预防剖宫产产妇椎管内麻醉后出现低血压中,使用去氧肾上腺素有显著的优势,不良反应发生率也较低,产妇在分娩过程中更加安全,值得应用。
Objective To compare the clinical effects of ephedrine and deoxyadrenaline in preventing supine hypotension syndrome in cesarean section.Methods 150 cases of cesarean section pregnant women admitted to the hospital from January 2016 to June 2018 were randomly divided into observation group and control group,each of 75 cases.Both groups were given intraspinal anesthesia.Control group received ephedrine injection 5 mg for the first time,and then added 5 mg for each time according to blood pressure.In observation group,5 μg/kg of deoxyepinephrine was injected intravenously,and then 5 μg/kg of deoxyepinephrine was added intravenously according to blood pressure.The cesarean section time,intraoperative fluid volume,MAP,HR,neonatal Apgar score and adverse reactions were compared between two groups.Results There was no significant difference in cesarean section operation time and intraoperative fluid volume in two groups(P>0.05).The MAP and neonatal Apgar scores in observation group were higher than those in control group,and the HR was lower than control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in observation group was 12.00% lower than 30.67% in control group,and the difference was statistically significant(χ^2=5.76,P<0.05).Conclusion In the prevention of hypotension after intraspinal anesthesia in cesarean section women,the use of deoxyepinephrine has a significant advantage,and the incidence of adverse reactions is low.The maternal is safer in the process of delivery,which is worthy of application.
作者
钱瑛
QIAN Ying(Department of Anesthesiology,The Traditional Chinese Medicine Hospital of Haimen,Jiangsu Province,Haimen 226100,China)
出处
《临床合理用药杂志》
2019年第31期34-35,共2页
Chinese Journal of Clinical Rational Drug Use
关键词
麻黄碱
去氧肾上腺素
椎管内麻醉
低血压
Ephedrine
Deoxyepinephrine
Intraspinal anesthesia
Hypotension
